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Fgl2 fibrinogen-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84586, updated on 9-Dec-2024

Summary

Official Symbol
Fgl2provided by RGD
Official Full Name
fibrinogen-like 2provided by RGD
Primary source
RGD:620170
See related
EnsemblRapid:ENSRNOG00000012881 AllianceGenome:RGD:620170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable peptidase activator activity. Predicted to be involved in parturition. Predicted to act upstream of or within several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of antigen processing and presentation; and negative regulation of memory T cell differentiation. Predicted to be located in cell surface. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human FGL2 (fibrinogen like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 372.1), Lung (RPKM 331.7) and 9 other tissues See more
Orthologs
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Genomic context

See Fgl2 in Genome Data Viewer
Location:
4q11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14602762..14608405, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13710566..13716207, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10323598..10329241, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 13 Neighboring gene small nucleolar RNA SNORD86 Neighboring gene uncharacterized LOC134486551 Neighboring gene family with sequence similarity 185, member A Neighboring gene coiled-coil domain containing 146 Neighboring gene uncharacterized LOC120102212 Neighboring gene gamma-secretase activating protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053455.2NP_445907.2  fibroleukin precursor

    See identical proteins and their annotated locations for NP_445907.2

    Status: VALIDATED

    Source sequence(s)
    BC072502, CB582252
    UniProtKB/TrEMBL
    A6K5C1, G3V7P2, Q32Q89
    Related
    ENSRNOP00000017232.4, ENSRNOT00000017232.7
    Conserved Domains (2) summary
    pfam00147
    Location:199425
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    cl21509
    Location:71177
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    14602762..14608405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)