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MT4 metallothionein 4 [ Homo sapiens (human) ]

Gene ID: 84560, updated on 5-Aug-2022

Summary

Official Symbol
MT4provided by HGNC
Official Full Name
metallothionein 4provided by HGNC
Primary source
HGNC:HGNC:18705
See related
Ensembl:ENSG00000102891 MIM:606206; AllianceGenome:HGNC:18705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT-4; MTIV; MT-IV
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in cellular response to metal ion; cellular zinc ion homeostasis; and detoxification of copper ion. Predicted to act upstream of or within cellular metal ion homeostasis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MT4 in Genome Data Viewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56565073..56568957)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62359992..62363895)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56598985..56602869)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 1 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene uncharacterized LOC105371283 Neighboring gene U7 small nuclear RNA Neighboring gene metallothionein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
metallothionein-4
Names
metallothionein-IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032935.3NP_116324.2  metallothionein-4

    Status: VALIDATED

    Source sequence(s)
    AC026461
    Consensus CDS
    CCDS42165.1
    UniProtKB/Swiss-Prot
    Q14DA1
    Related
    ENSP00000219162.3, ENST00000219162.4
    Conserved Domains (1) summary
    pfam00131
    Location:561
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    56565073..56568957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    62359992..62363895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)