Format

Send to:

Choose Destination

FAXC failed axon connections homolog, metaxin like GST domain containing [ Homo sapiens (human) ]

Gene ID: 84553, updated on 11-Jun-2021

Summary

Official Symbol
FAXCprovided by HGNC
Official Full Name
failed axon connections homolog, metaxin like GST domain containingprovided by HGNC
Primary source
HGNC:HGNC:20742
See related
Ensembl:ENSG00000146267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf168; dJ273F20
Expression
Biased expression in brain (RPKM 5.0), prostate (RPKM 1.1) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FAXC in Genome Data Viewer
Location:
6q16.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (99271161..99350056, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (99719037..99797932, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene microRNA 548ai Neighboring gene 3-hydroxybutyrate dehydrogenase 2, pseudogene 1 Neighboring gene coenzyme Q3, methyltransferase Neighboring gene uncharacterized LOC101927365 Neighboring gene PNN interacting serine and arginine rich protein Neighboring gene thiosulfate sulfurtransferase like domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of behavioral disinhibition.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2817, FLJ30539

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
failed axon connections homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051943.1 RefSeqGene

    Range
    5637..84143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346530.2NP_001333459.1  failed axon connections homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL034371
    UniProtKB/Swiss-Prot
    Q5TGI0
    Conserved Domains (2) summary
    pfam17171
    Location:142205
    GST_C_6; Glutathione S-transferase, C-terminal domain
    pfam17172
    Location:291
    GST_N_4; Glutathione S-transferase N-terminal domain
  2. NM_001346531.2NP_001333460.1  failed axon connections homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL034371
    Conserved Domains (2) summary
    pfam17171
    Location:210273
    GST_C_6; Glutathione S-transferase, C-terminal domain
    pfam17172
    Location:64159
    GST_N_4; Glutathione S-transferase N-terminal domain
  3. NM_001346532.1NP_001333461.1  failed axon connections homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL034371
    Conserved Domains (2) summary
    pfam17171
    Location:210273
    GST_C_6; Glutathione S-transferase, C-terminal domain
    pfam17172
    Location:64159
    GST_N_4; Glutathione S-transferase N-terminal domain
  4. NM_001346533.1NP_001333462.1  failed axon connections homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL034371
    UniProtKB/Swiss-Prot
    Q5TGI0
    Conserved Domains (2) summary
    pfam17171
    Location:142205
    GST_C_6; Glutathione S-transferase, C-terminal domain
    pfam17172
    Location:291
    GST_N_4; Glutathione S-transferase N-terminal domain
  5. NM_032511.4NP_115900.1  failed axon connections homolog isoform 1

    See identical proteins and their annotated locations for NP_115900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK055101, AL034371, BC004869, BQ883579
    Consensus CDS
    CCDS34500.1
    UniProtKB/Swiss-Prot
    Q5TGI0
    Related
    ENSP00000374328.4, ENST00000389677.6
    Conserved Domains (2) summary
    pfam17171
    Location:263326
    GST_C_6; Glutathione S-transferase, C-terminal domain
    pfam17172
    Location:117212
    GST_N_4; Glutathione S-transferase N-terminal domain

RNA

  1. NR_144463.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL034371
  2. NR_144464.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL034371

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    99271161..99350056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715582.2XP_006715645.1  failed axon connections homolog isoform X2

    Conserved Domains (1) summary
    cd03193
    Location:42111
    GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
  2. XM_011536189.3XP_011534491.1  failed axon connections homolog isoform X1

    Conserved Domains (1) summary
    cd03080
    Location:99172
    GST_N_Metaxin_like; GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It ...
Support Center