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MCHR2 melanin concentrating hormone receptor 2 [ Homo sapiens (human) ]

Gene ID: 84539, updated on 5-Jan-2022

Summary

Official Symbol
MCHR2provided by HGNC
Official Full Name
melanin concentrating hormone receptor 2provided by HGNC
Primary source
HGNC:HGNC:20867
See related
Ensembl:ENSG00000152034 MIM:606111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLT; MCH2; MCH2R; GPR145; GPRv17; MCH-2R; MCH-R2; MCHR-2
Summary
Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in brain (RPKM 3.0) and testis (RPKM 2.4) See more
Orthologs
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Genomic context

See MCHR2 in Genome Data Viewer
Location:
6q16.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (99918519..99994223, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (100366395..100442099, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CCNC and PRDM13 intergenic region DNase I hypersensitve site DHS6S1 Neighboring gene PR/SET domain 13 Neighboring gene MCHR2 antisense RNA 1 Neighboring gene tetratricopeptide repeat domain 22 pseudogene Neighboring gene nucleophosmin 1 pseudogene 38

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
melanin-concentrating hormone receptor 2
Names
G protein-coupled receptor slt
G-protein coupled receptor 145
MCH receptor 2
melanin-concentrating hormone 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040179.2NP_001035269.1  melanin-concentrating hormone receptor 2

    See identical proteins and their annotated locations for NP_001035269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK123634, AL590725
    Consensus CDS
    CCDS5044.1
    UniProtKB/Swiss-Prot
    Q969V1
    Related
    ENSP00000281806.2, ENST00000281806.7
    Conserved Domains (1) summary
    cd15339
    Location:35317
    7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_032503.3NP_115892.2  melanin-concentrating hormone receptor 2

    See identical proteins and their annotated locations for NP_115892.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK123634, AL590725
    Consensus CDS
    CCDS5044.1
    UniProtKB/Swiss-Prot
    Q969V1
    Related
    ENSP00000358214.1, ENST00000369212.2
    Conserved Domains (1) summary
    cd15339
    Location:35317
    7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    99918519..99994223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446571.1XP_024302339.1  melanin-concentrating hormone receptor 2 isoform X1

    Conserved Domains (1) summary
    cd15339
    Location:35317
    7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
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