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CDIN1 CDAN1 interacting nuclease 1 [ Homo sapiens (human) ]

Gene ID: 84529, updated on 6-Sep-2021

Summary

Official Symbol
CDIN1provided by HGNC
Official Full Name
CDAN1 interacting nuclease 1provided by HGNC
Primary source
HGNC:HGNC:26929
See related
Ensembl:ENSG00000186073 MIM:615626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH114; C15orf41
Summary
This gene encodes a protein with two predicted helix-turn-helix domains. Mutations in this gene were found in families with congenital dyserythropoietic anemia type Ib. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Expression
Broad expression in heart (RPKM 18.6), urinary bladder (RPKM 3.9) and 17 other tissues See more
Orthologs
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Genomic context

See CDIN1 in Genome Data Viewer
Location:
15q14
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (36579611..36810248)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (36871827..37102445)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs355 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 4 Neighboring gene tropomyosin 3 pseudogene Neighboring gene LARP4 pseudogene Neighboring gene tyrosylprotein sulfotransferase 2 pseudogene 1 Neighboring gene VISTA enhancer hs828 Neighboring gene casein kinase 1 alpha 1 pseudogene 1 Neighboring gene uncharacterized LOC145845 Neighboring gene Meis homeobox 2 Neighboring gene VISTA enhancer hs181

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22851, MGC11326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CDAN1-interacting nuclease 1
Names
protein C15orf41
uncharacterized protein C15orf41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034055.1 RefSeqGene

    Range
    5024..235642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130010.3NP_001123482.1  CDAN1-interacting nuclease 1 isoform 1

    See identical proteins and their annotated locations for NP_001123482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA581466, AL526474, BC006254, BX647650, DA467314
    Consensus CDS
    CCDS45215.1
    UniProtKB/Swiss-Prot
    Q9Y2V0
    Related
    ENSP00000401362.2, ENST00000437989.6
    Conserved Domains (1) summary
    pfam14811
    Location:135265
    TPD; Protein of unknown function TPD sequence-motif
  2. NM_001290232.2NP_001277161.1  CDAN1-interacting nuclease 1 isoform 2

    See identical proteins and their annotated locations for NP_001277161.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC013640, AC019016, AC103988, AK315446
    Consensus CDS
    CCDS45216.1
    UniProtKB/Swiss-Prot
    Q9Y2V0
    Related
    ENSP00000457854.1, ENST00000562877.5
    Conserved Domains (1) summary
    pfam14811
    Location:37167
    TPD; Protein of unknown function TPD sequence-motif
  3. NM_001290233.2NP_001277162.1  CDAN1-interacting nuclease 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-temrinus and is longer than isoform 1.
    Source sequence(s)
    AC013640, AC103988, AK026504, BC006254
    Consensus CDS
    CCDS86445.1
    UniProtKB/Swiss-Prot
    Q9Y2V0
    Related
    ENSP00000493669.1, ENST00000570265.6
    Conserved Domains (1) summary
    pfam14811
    Location:135241
    TPD; Protein of unknown function TPD sequence-motif
  4. NM_001321756.2NP_001308685.1  CDAN1-interacting nuclease 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013640, AC019016, AC103988
    Consensus CDS
    CCDS45216.1
    UniProtKB/Swiss-Prot
    Q9Y2V0
    Conserved Domains (1) summary
    pfam14811
    Location:37167
    TPD; Protein of unknown function TPD sequence-motif
  5. NM_001321757.2NP_001308686.1  CDAN1-interacting nuclease 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC013640, AC019016, AC103988
    Consensus CDS
    CCDS86447.1
    Related
    ENSP00000496325.1, ENST00000643612.1
    Conserved Domains (1) summary
    pfam14811
    Location:12142
    TPD; Protein of unknown function TPD sequence-motif
  6. NM_001321758.2NP_001308687.1  CDAN1-interacting nuclease 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC013640, AC019016, AC103988
    Conserved Domains (1) summary
    pfam14811
    Location:98228
    TPD; Protein of unknown function TPD sequence-motif
  7. NM_001321759.2NP_001308688.1  CDAN1-interacting nuclease 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC013640, AC019016, AC103988
    Consensus CDS
    CCDS45215.1
    UniProtKB/Swiss-Prot
    Q9Y2V0
    Related
    ENSP00000455397.1, ENST00000566621.6
    Conserved Domains (1) summary
    pfam14811
    Location:135265
    TPD; Protein of unknown function TPD sequence-motif
  8. NM_001321760.2NP_001308689.1  CDAN1-interacting nuclease 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC013640, AC019016, AC103988
    Consensus CDS
    CCDS86446.1
    Related
    ENSP00000494718.1, ENST00000646533.1
    Conserved Domains (1) summary
    pfam14811
    Location:135203
    TPD; Protein of unknown function TPD sequence-motif
  9. NM_001321761.2NP_001308690.1  CDAN1-interacting nuclease 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC013640, AC019016, AC103988
    Consensus CDS
    CCDS81861.1
    UniProtKB/TrEMBL
    H3BS01
    Related
    ENSP00000456477.1, ENST00000569302.6
    Conserved Domains (1) summary
    pfam14811
    Location:135271
    TPD; Protein of unknown function TPD sequence-motif
  10. NM_032499.6NP_115888.1  CDAN1-interacting nuclease 1 isoform 2

    See identical proteins and their annotated locations for NP_115888.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AA581466, AC013640, AC103988, AF114263, AL526474, BX647650, DA534917
    Consensus CDS
    CCDS45216.1
    UniProtKB/Swiss-Prot
    Q9Y2V0
    Related
    ENSP00000456736.1, ENST00000567389.5
    Conserved Domains (1) summary
    pfam14811
    Location:37167
    TPD; Protein of unknown function TPD sequence-motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    36579611..36810248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022676.1XP_016878165.1  CDAN1-interacting nuclease 1 isoform X1

    Conserved Domains (1) summary
    pfam14811
    Location:103199
    TPD; Protein of unknown function TPD sequence-motif
  2. XM_017022677.1XP_016878166.1  CDAN1-interacting nuclease 1 isoform X1

    Conserved Domains (1) summary
    pfam14811
    Location:103199
    TPD; Protein of unknown function TPD sequence-motif
  3. XM_024450088.1XP_024305856.1  CDAN1-interacting nuclease 1 isoform X2

    Related
    ENSP00000342433.4, ENST00000338183.8
    Conserved Domains (1) summary
    pfam14811
    Location:37167
    TPD; Protein of unknown function TPD sequence-motif

RNA

  1. XR_931922.1 RNA Sequence

  2. XR_931924.1 RNA Sequence

  3. XR_002957689.1 RNA Sequence

  4. XR_931921.1 RNA Sequence

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