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HOPX HOP homeobox [ Homo sapiens (human) ]

Gene ID: 84525, updated on 7-Dec-2018

Summary

Official Symbol
HOPXprovided by HGNC
Official Full Name
HOP homeoboxprovided by HGNC
Primary source
HGNC:HGNC:24961
See related
Ensembl:ENSG00000171476 MIM:607275
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOD; HOP; OB1; LAGY; TOTO; CAMEO; NECC1; SMAP31
Summary
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]
Expression
Biased expression in skin (RPKM 80.6), esophagus (RPKM 62.3) and 8 other tissues See more
Orthologs

Genomic context

See HOPX in Genome Data Viewer
Location:
4q12
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (56647988..56681866, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (57514154..57547874, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377665 Neighboring gene ADP ribosylation factor like GTPase 9 Neighboring gene theg spermatid protein like Neighboring gene glycine decarboxylase pseudogene 1 Neighboring gene uncharacterized LOC105377666 Neighboring gene cardiac hypertrophy associated epigenetic regulator 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
trophectodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeodomain-only protein
Names
lung cancer-associated Y protein
not expressed in choriocarcinoma clone 1
odd homeobox protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050687.1 RefSeqGene

    Range
    5001..38719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145459.1NP_001138931.1  homeodomain-only protein isoform b

    See identical proteins and their annotated locations for NP_001138931.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AA504137, AB059410, CB996541, DB180848
    Consensus CDS
    CCDS3507.1
    UniProtKB/Swiss-Prot
    Q9BPY8
    Related
    ENSP00000370654.3, ENST00000381255.7
    Conserved Domains (1) summary
    cd00086
    Location:1062
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_001145460.1NP_001138932.1  homeodomain-only protein isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes an alternate exon in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AA504137, AB059408, AF492679, CK002567, DA512059
    Consensus CDS
    CCDS54767.1
    UniProtKB/Swiss-Prot
    Q9BPY8
    Related
    ENSP00000450527.1, ENST00000554144.5
    Conserved Domains (1) summary
    cd00086
    Location:2866
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. NM_032495.6NP_115884.4  homeodomain-only protein isoform a

    See identical proteins and their annotated locations for NP_115884.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AB059408, DA512059
    Consensus CDS
    CCDS47062.1
    UniProtKB/Swiss-Prot
    Q9BPY8
    Related
    ENSP00000396275.1, ENST00000420433.5
    Conserved Domains (1) summary
    cd00086
    Location:2880
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  4. NM_139211.4NP_631957.1  homeodomain-only protein isoform b

    See identical proteins and their annotated locations for NP_631957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AA504137, AB059410, DB180848
    Consensus CDS
    CCDS3507.1
    UniProtKB/Swiss-Prot
    Q9BPY8
    Related
    ENSP00000452003.1, ENST00000556614.6
    Conserved Domains (1) summary
    cd00086
    Location:1062
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  5. NM_139212.3NP_631958.1  homeodomain-only protein isoform b

    See identical proteins and their annotated locations for NP_631958.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AA504137, AF454763, AK289707, DA512059
    Consensus CDS
    CCDS3507.1
    UniProtKB/Swiss-Prot
    Q9BPY8
    Related
    ENSP00000337330.7, ENST00000337881.11
    Conserved Domains (1) summary
    cd00086
    Location:1062
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    56647988..56681866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008728.1XP_016864217.1  homeodomain-only protein isoform X1

    Conserved Domains (1) summary
    cd00086
    Location:2577
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. XM_017008732.1XP_016864221.1  homeodomain-only protein isoform X3

    UniProtKB/Swiss-Prot
    Q9BPY8
    Related
    ENSP00000451794.1, ENST00000556376.6
    Conserved Domains (1) summary
    cd00086
    Location:1062
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. XM_017008729.2XP_016864218.2  homeodomain-only protein isoform X2

    Conserved Domains (1) summary
    cd00086
    Location:48100
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  4. XM_017008733.1XP_016864222.1  homeodomain-only protein isoform X3

    UniProtKB/Swiss-Prot
    Q9BPY8
    Related
    ENSP00000424101.2, ENST00000503639.7
    Conserved Domains (1) summary
    cd00086
    Location:1062
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  5. XM_017008730.2XP_016864219.1  homeodomain-only protein isoform X3

    UniProtKB/Swiss-Prot
    Q9BPY8
    Conserved Domains (1) summary
    cd00086
    Location:1062
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  6. XM_017008731.2XP_016864220.1  homeodomain-only protein isoform X3

    UniProtKB/Swiss-Prot
    Q9BPY8
    Related
    ENSP00000452098.1, ENST00000555760.6
    Conserved Domains (1) summary
    cd00086
    Location:1062
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  7. XM_017008734.1XP_016864223.1  homeodomain-only protein isoform X3

    UniProtKB/Swiss-Prot
    Q9BPY8
    Related
    ENSP00000452340.1, ENST00000553379.6
    Conserved Domains (1) summary
    cd00086
    Location:1062
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  8. XM_006714052.2XP_006714115.1  homeodomain-only protein isoform X4

    See identical proteins and their annotated locations for XP_006714115.1

    Conserved Domains (1) summary
    cd00086
    Location:2866
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
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