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ZC3H8 zinc finger CCCH-type containing 8 [ Homo sapiens (human) ]

Gene ID: 84524, updated on 5-Sep-2021

Summary

Official Symbol
ZC3H8provided by HGNC
Official Full Name
zinc finger CCCH-type containing 8provided by HGNC
Primary source
HGNC:HGNC:30941
See related
Ensembl:ENSG00000144161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fliz1; ZC3HDC8
Expression
Ubiquitous expression in testis (RPKM 3.7), thyroid (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZC3H8 in Genome Data Viewer
Location:
2q14.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (112211529..112255042, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (112969106..113012619, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MER proto-oncogene, tyrosine kinase Neighboring gene Sharpr-MPRA regulatory region 3720 Neighboring gene uncharacterized LOC105373560 Neighboring gene transmembrane protein 87B Neighboring gene fibulin 7 Neighboring gene CRISPRi-validated cis-regulatory element chr2.4107 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 6 Neighboring gene zinc finger CCCH-type containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in histone locus body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription elongation factor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in transcriptionally active chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 8
Names
zinc finger CCCH-type domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032494.3NP_115883.2  zinc finger CCCH domain-containing protein 8

    See identical proteins and their annotated locations for NP_115883.2

    Status: VALIDATED

    Source sequence(s)
    AC092645, AF334161, BG773518, CV574571
    Consensus CDS
    CCDS46392.1
    UniProtKB/Swiss-Prot
    Q8N5P1
    Related
    ENSP00000386488.1, ENST00000409573.7
    Conserved Domains (1) summary
    smart00356
    Location:226246
    ZnF_C3H1; zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    112211529..112255042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005107.1XP_016860596.1  zinc finger CCCH domain-containing protein 8 isoform X1

    Conserved Domains (1) summary
    COG5084
    Location:48166
    YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
  2. XM_024453174.1XP_024308942.1  zinc finger CCCH domain-containing protein 8 isoform X1

    Conserved Domains (1) summary
    COG5084
    Location:48166
    YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
  3. XM_024453175.1XP_024308943.1  zinc finger CCCH domain-containing protein 8 isoform X1

    Conserved Domains (1) summary
    COG5084
    Location:48166
    YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]

RNA

  1. XR_001738994.1 RNA Sequence

  2. XR_001738995.2 RNA Sequence

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