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ZC3H8 zinc finger CCCH-type containing 8 [ Homo sapiens (human) ]

Gene ID: 84524, updated on 4-Dec-2022

Summary

Official Symbol
ZC3H8provided by HGNC
Official Full Name
zinc finger CCCH-type containing 8provided by HGNC
Primary source
HGNC:HGNC:30941
See related
Ensembl:ENSG00000144161 AllianceGenome:HGNC:30941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fliz1; ZC3HDC8
Summary
Enables RNA binding activity. Involved in several processes, including positive regulation of thymocyte apoptotic process; regulation of transcription, DNA-templated; and snRNA transcription. Located in Cajal body; histone locus body; and transcriptionally active chromatin. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 3.7), thyroid (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZC3H8 in Genome Data Viewer
Location:
2q14.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (112211529..112255042, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (112638397..112681917, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (112969106..113012619, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MER proto-oncogene, tyrosine kinase Neighboring gene Sharpr-MPRA regulatory region 10261 Neighboring gene transmembrane protein 87B Neighboring gene fibulin 7 Neighboring gene CRISPRi-validated cis-regulatory element chr2.4107 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in histone locus body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription elongation factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 8
Names
zinc finger CCCH-type domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032494.3NP_115883.2  zinc finger CCCH domain-containing protein 8

    See identical proteins and their annotated locations for NP_115883.2

    Status: VALIDATED

    Source sequence(s)
    AC092645, AF334161, BG773518, CV574571
    Consensus CDS
    CCDS46392.1
    UniProtKB/Swiss-Prot
    Q8N5P1, Q9BZ75
    Related
    ENSP00000386488.1, ENST00000409573.7
    Conserved Domains (1) summary
    smart00356
    Location:226246
    ZnF_C3H1; zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    112211529..112255042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001738994.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    112638397..112681917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)