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ACRBP acrosin binding protein [ Homo sapiens (human) ]

Gene ID: 84519, updated on 25-Jan-2022


Official Symbol
ACRBPprovided by HGNC
Official Full Name
acrosin binding proteinprovided by HGNC
Primary source
See related
Ensembl:ENSG00000111644 MIM:608352; AllianceGenome:HGNC:17195
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT23; SP32; OY-TES-1
The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]
Restricted expression toward testis (RPKM 162.2) See more
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Genomic context

See ACRBP in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6638075..6647432, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6747241..6756598, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr12.325 Neighboring gene uncharacterized LOC105369631 Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene inhibitor of growth family member 4 Neighboring gene zinc finger protein 384

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Potential readthrough

Included gene: LPAR5


Clone Names

  • FLJ51160

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
Process Evidence Code Pubs
involved_in acrosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
involved_in biological_process ND
No biological Data available
more info
involved_in fertilization ISS
Inferred from Sequence or Structural Similarity
more info
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
Component Evidence Code Pubs
located_in acrosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
located_in acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
located_in nucleus HDA PubMed 

General protein information

Preferred Names
acrosin-binding protein
acrosin-binding protein, 60 kDa form
cancer/testis antigen 23
cancer/testis antigen OY-TES-1
proacrosin binding protein sp32
testicular tissue protein Li 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032489.3NP_115878.2  acrosin-binding protein precursor

    See identical proteins and their annotated locations for NP_115878.2

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    ENSP00000229243.2, ENST00000229243.7
    Conserved Domains (1) summary
    PBP_sp32; Proacrosin binding protein sp32

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    6638075..6647432 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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