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NKX6-2 NK6 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 84504, updated on 9-Aug-2021

Summary

Official Symbol
NKX6-2provided by HGNC
Official Full Name
NK6 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:19321
See related
Ensembl:ENSG00000148826 MIM:605955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTX; NKX6B; SPAX8; NKX6.2
Expression
Ubiquitous expression in stomach (RPKM 17.5), brain (RPKM 14.0) and 25 other tissues See more
Orthologs
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Genomic context

See NKX6-2 in Genome Data Viewer
Location:
10q26.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (132782229..132786147, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134596685..134599651, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984282 Neighboring gene inositol polyphosphate-5-phosphatase A Neighboring gene VISTA enhancer hs1763 Neighboring gene cilia and flagella associated protein 46 Neighboring gene uncharacterized LOC105378571 Neighboring gene uncharacterized LOC105378572 Neighboring gene long intergenic non-protein coding RNA 1166

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC126684

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
homeobox protein Nkx-6.2
Names
NK homeobox family 6, B
NK6 transcription factor related, locus 2
glial and testis-specific homeobox protein
homeobox 6B
homeobox protein NK-6 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177400.3NP_796374.2  homeobox protein Nkx-6.2

    Status: VALIDATED

    Source sequence(s)
    AL392043
    Consensus CDS
    CCDS7670.1
    Related
    ENSP00000357581.5, ENST00000368592.8
    Conserved Domains (1) summary
    pfam00046
    Location:151204
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    132782229..132786147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016789.2XP_016872278.1  homeobox protein Nkx-6.2 isoform X1

    UniProtKB/Swiss-Prot
    Q9C056
    Conserved Domains (1) summary
    pfam00046
    Location:151204
    Homeobox; Homeobox domain
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