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ZNF527 zinc finger protein 527 [ Homo sapiens (human) ]

Gene ID: 84503, updated on 13-May-2022

Summary

Official Symbol
ZNF527provided by HGNC
Official Full Name
zinc finger protein 527provided by HGNC
Primary source
HGNC:HGNC:29385
See related
Ensembl:ENSG00000189164 AllianceGenome:HGNC:29385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 1.6), ovary (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF527 in Genome Data Viewer
Location:
19q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37371099..37393066)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40172613..40194581)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37862001..37883968)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC284412 Neighboring gene zinc finger protein 875 Neighboring gene zinc finger protein 569 Neighboring gene zinc finger protein 570 Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene zinc finger protein 793

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032453.2NP_115829.1  zinc finger protein 527

    See identical proteins and their annotated locations for NP_115829.1

    Status: VALIDATED

    Source sequence(s)
    AC008806, DC341389
    Consensus CDS
    CCDS42559.1
    UniProtKB/Swiss-Prot
    Q8NB42
    Related
    ENSP00000390179.2, ENST00000436120.7
    Conserved Domains (5) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:328490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:360380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:400425
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37371099..37393066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259329.5XP_005259386.1  zinc finger protein 527 isoform X1

    See identical proteins and their annotated locations for XP_005259386.1

    UniProtKB/Swiss-Prot
    Q8NB42
    Conserved Domains (5) summary
    smart00349
    Location:1454
    KRAB; krueppel associated box
    COG5048
    Location:296458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:368393
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005259328.6XP_005259385.1  zinc finger protein 527 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:296458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:368393
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017027381.2XP_016882870.1  zinc finger protein 527 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:264426
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:296316
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:336361
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017027380.2XP_016882869.1  zinc finger protein 527 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:267429
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299319
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:339364
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40172613..40194581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)