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SPIRE2 spire type actin nucleation factor 2 [ Homo sapiens (human) ]

Gene ID: 84501, updated on 29-Mar-2020

Summary

Official Symbol
SPIRE2provided by HGNC
Official Full Name
spire type actin nucleation factor 2provided by HGNC
Primary source
HGNC:HGNC:30623
See related
Ensembl:ENSG00000204991 MIM:609217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Spir-2
Expression
Broad expression in stomach (RPKM 4.5), colon (RPKM 4.1) and 20 other tissues See more
Orthologs

Genomic context

See SPIRE2 in Genome Data Viewer
Location:
16q24.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (89828475..89871319)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89894883..89937727)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene VPS9 domain containing 1 Neighboring gene zinc finger protein 276 Neighboring gene FA complementation group A Neighboring gene Sharpr-MPRA regulatory region 3988 Neighboring gene uncharacterized LOC107984817 Neighboring gene uncharacterized LOC105371419 Neighboring gene uncharacterized LOC112268179 Neighboring gene transcription factor 25 Neighboring gene melanocortin 1 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin nucleation IEA
Inferred from Electronic Annotation
more info
 
cleavage furrow formation ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of meiotic spindle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
formin-nucleated actin cable assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular transport ISS
Inferred from Sequence or Structural Similarity
more info
 
polar body extrusion after meiotic divisions ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with cleavage furrow ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein spire homolog 2
Names
spire actin nucleation factor 2
spire family actin nucleation factor 2
spire homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032451.2NP_115827.1  protein spire homolog 2

    See identical proteins and their annotated locations for NP_115827.1

    Status: VALIDATED

    Source sequence(s)
    AC092385, AJ422077, AL834408, BC011119, BX439688
    Consensus CDS
    CCDS32516.1
    UniProtKB/Swiss-Prot
    Q8WWL2
    Related
    ENSP00000367494.3, ENST00000378247.8
    Conserved Domains (2) summary
    cd15768
    Location:566680
    FYVE_SPIR2; FYVE-related domain found in protein spire homolog 2 (Spire2) and similar proteins
    pfam16474
    Location:22208
    KIND; Kinase non-catalytic C-lobe domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    89828475..89871319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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