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Qsox1 quiescin sulfhydryl oxidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84491, updated on 12-Jan-2022

Summary

Official Symbol
Qsox1provided by RGD
Official Full Name
quiescin sulfhydryl oxidase 1provided by RGD
Primary source
RGD:68957
See related
Ensembl:ENSRNOG00000003649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Qsox; rSOx; Qscn6; Sox-2
Summary
Enables FAD binding activity and flavin-linked sulfhydryl oxidase activity. Predicted to be involved in extracellular matrix assembly; negative regulation of macroautophagy; and protein folding. Located in extracellular space. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Liver (RPKM 144.4), Heart (RPKM 82.7) and 9 other tissues See more
Orthologs
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Genomic context

See Qsox1 in Genome Data Viewer
Location:
13q21
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (67949780..67987434, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (73423396..73460890, complement)

Chromosome 13 - NC_051348.1Genomic Context describing neighboring genes Neighboring gene deoxyuridine triphosphatase pseudogene Neighboring gene acyl-CoA binding domain containing 6 Neighboring gene 60S ribosomal protein L37-like Neighboring gene LIM homeobox 4 Neighboring gene uncharacterized LOC120096287 Neighboring gene centrosomal protein 350 Neighboring gene similar to interferon induced transmembrane protein 2 (1-8D)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables FAD binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin-linked sulfhydryl oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin-linked sulfhydryl oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin-linked sulfhydryl oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables flavin-linked sulfhydryl oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein disulfide isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sulfhydryl oxidase 1
Names
FAD-dependent sulfhydryl oxidase-2
quiescin Q6 sulfhydryl oxidase 1
rQSOX
NP_001103368.1
NP_445883.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109898.1NP_001103368.1  sulfhydryl oxidase 1 isoform A precursor

    See identical proteins and their annotated locations for NP_001103368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AB044285, AF217799, AY623665, BM387067
    UniProtKB/Swiss-Prot
    Q6IUU3
    Related
    ENSRNOP00000061072.2, ENSRNOT00000068044.4
    Conserved Domains (2) summary
    cd02992
    Location:43155
    PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
    pfam04777
    Location:409504
    Evr1_Alr; Erv1 / Alr family
  2. NM_053431.3NP_445883.1  sulfhydryl oxidase 1 isoform B precursor

    See identical proteins and their annotated locations for NP_445883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform B which has a shorter, distinct C-terminus when compared to isoform A
    Source sequence(s)
    AB044285, AF217799, BM387067
    UniProtKB/Swiss-Prot
    Q6IUU3
    Related
    ENSRNOP00000005052.6, ENSRNOT00000005052.10
    Conserved Domains (2) summary
    cd02992
    Location:43155
    PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
    pfam04777
    Location:409504
    Evr1_Alr; Erv1 / Alr family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051348.1 Reference mRatBN7.2 Primary Assembly

    Range
    67949780..67987434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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