Format

Send to:

Choose Destination

DHX16 DEAH-box helicase 16 [ Homo sapiens (human) ]

Gene ID: 8449, updated on 25-Nov-2021

Summary

Official Symbol
DHX16provided by HGNC
Official Full Name
DEAH-box helicase 16provided by HGNC
Primary source
HGNC:HGNC:2739
See related
Ensembl:ENSG00000204560 MIM:603405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBP2; PRP8; Prp2; DDX16; NMOAS; PRPF2; PRO2014
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]
Expression
Ubiquitous expression in testis (RPKM 17.0), spleen (RPKM 9.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DHX16 in Genome Data Viewer
Location:
6p21.33
Exon count:
24
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30653127..30673006, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30620904..30640783, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13793 Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin alpha pseudogene 1 Neighboring gene chromosome 6 open reading frame 136 Neighboring gene protein phosphatase 1 regulatory subunit 18 Neighboring gene Sharpr-MPRA regulatory region 567 Neighboring gene nurim

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16) at amino acid residues 314-315 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity EXP
Inferred from Experiment
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing TAS
Traceable Author Statement
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Names
ATP-dependent RNA helicase #3
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16
DEAD/H box 16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
DEAH-box protein 16
RNA helicase
putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
NP_001157711.1
NP_001350444.1
NP_003578.2
XP_011513240.1
XP_011513241.1
XP_011513243.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164239.2NP_001157711.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 2

    See identical proteins and their annotated locations for NP_001157711.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK302721, BC008825, BQ772493
    UniProtKB/Swiss-Prot
    O60231
    UniProtKB/TrEMBL
    A0A1U9X7L7, B4DZ28
    Conserved Domains (2) summary
    COG1643
    Location:330968
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cl26511
    Location:88316
    Neuromodulin_N; Gap junction protein N-terminal region
  2. NM_001363515.2NP_001350444.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL662798
    Consensus CDS
    CCDS87382.1
    Related
    ENSP00000365620.5, ENST00000376437.9
    Conserved Domains (1) summary
    COG1643
    Location:7547
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  3. NM_003587.5NP_003578.2  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 1

    See identical proteins and their annotated locations for NP_003578.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC008825, BQ772493, DB072495
    Consensus CDS
    CCDS4685.1
    UniProtKB/Swiss-Prot
    O60231
    UniProtKB/TrEMBL
    Q5SQH4
    Related
    ENSP00000365625.3, ENST00000376442.8
    Conserved Domains (2) summary
    PTZ00121
    Location:148376
    PTZ00121; MAEBL; Provisional
    COG1643
    Location:3901028
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30653127..30673006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514939.2XP_011513241.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    See identical proteins and their annotated locations for XP_011513241.1

    Conserved Domains (5) summary
    smart00487
    Location:100282
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:499583
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:117256
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:281438
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam07717
    Location:618716
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  2. XM_011514938.2XP_011513240.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    See identical proteins and their annotated locations for XP_011513240.1

    Conserved Domains (5) summary
    smart00487
    Location:100282
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:499583
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:117256
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:281438
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam07717
    Location:618716
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  3. XM_011514941.3XP_011513243.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X3

    See identical proteins and their annotated locations for XP_011513243.1

    Conserved Domains (5) summary
    smart00847
    Location:281365
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:1511
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:138
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:63220
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam07717
    Location:400498
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1988954..2002512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    2132841..2152750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1908950..1928860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    1963351..1983259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    1997177..2017083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1908209..1928119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    1953878..1973789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center