Format

Send to:

Choose Destination

Synrg synergin, gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 84479, updated on 12-Jan-2022

Summary

Official Symbol
Synrgprovided by RGD
Official Full Name
synergin, gammaprovided by RGD
Primary source
RGD:620684
See related
Ensembl:ENSRNOG00000053814
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Syng; Ap1gbp1
Summary
Predicted to be involved in endocytosis and protein transport. Part of clathrin coat of trans-Golgi network vesicle. Orthologous to human SYNRG (synergin gamma). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Thymus (RPKM 117.1), Kidney (RPKM 115.5) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Synrg in Genome Data Viewer
Location:
10q26
Exon count:
24
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68848828..68931252)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (71278698..71357791)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene HNF1 homeobox B Neighboring gene DExD-box helicase 52 Neighboring gene hCG1994130-like Neighboring gene dual specificity phosphatase 14 Neighboring gene transcriptional adaptor 2A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of clathrin coat of trans-Golgi network vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of clathrin coat of trans-Golgi network vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synergin gamma
Names
AP1 subunit gamma-binding protein 1
gamma-synergin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053419.1NP_445871.1  synergin gamma

    See identical proteins and their annotated locations for NP_445871.1

    Status: PROVISIONAL

    Source sequence(s)
    EF121981
    UniProtKB/Swiss-Prot
    Q9JKC9
    Related
    ENSRNOP00000071493.2, ENSRNOT00000087428.2
    Conserved Domains (2) summary
    cd00052
    Location:414465
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:113147
    dsDNA_bind; Double-stranded DNA-binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    68848828..68931252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086970.1XP_038942898.1  synergin gamma isoform X1

    Conserved Domains (4) summary
    PRK09510
    Location:100170
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    cd00052
    Location:414465
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30130
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00928
    Location:113147
    dsDNA_bind; Double-stranded DNA-binding domain
  2. XM_039086972.1XP_038942900.1  synergin gamma isoform X3

    Conserved Domains (4) summary
    PRK09510
    Location:100170
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    cd00052
    Location:414465
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30130
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00928
    Location:113147
    dsDNA_bind; Double-stranded DNA-binding domain
  3. XM_039086973.1XP_038942901.1  synergin gamma isoform X4

    Related
    ENSRNOP00000089038.1, ENSRNOT00000120087.1
    Conserved Domains (4) summary
    PRK09510
    Location:100170
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    cd00052
    Location:414465
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30130
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00928
    Location:113147
    dsDNA_bind; Double-stranded DNA-binding domain
  4. XM_039086971.1XP_038942899.1  synergin gamma isoform X2

    Conserved Domains (4) summary
    PRK09510
    Location:100170
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    cd00052
    Location:414465
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30130
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00928
    Location:113147
    dsDNA_bind; Double-stranded DNA-binding domain
  5. XM_039086974.1XP_038942902.1  synergin gamma isoform X5

    Conserved Domains (4) summary
    PRK09510
    Location:100170
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    cd00052
    Location:414465
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30130
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00928
    Location:113147
    dsDNA_bind; Double-stranded DNA-binding domain
  6. XM_039086975.1XP_038942903.1  synergin gamma isoform X6

    Conserved Domains (3) summary
    cd00052
    Location:313364
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30130
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00928
    Location:113147
    dsDNA_bind; Double-stranded DNA-binding domain
  7. XM_039086981.1XP_038942909.1  synergin gamma isoform X12

    Related
    ENSRNOP00000070940.2, ENSRNOT00000092020.2
    Conserved Domains (3) summary
    cd00052
    Location:313364
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30130
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00928
    Location:113147
    dsDNA_bind; Double-stranded DNA-binding domain
  8. XM_039086976.1XP_038942904.1  synergin gamma isoform X7

    Conserved Domains (3) summary
    cd00052
    Location:313364
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30130
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00928
    Location:113147
    dsDNA_bind; Double-stranded DNA-binding domain
  9. XM_039086977.1XP_038942905.1  synergin gamma isoform X8

    Conserved Domains (2) summary
    cd00052
    Location:235286
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30331
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  10. XM_039086982.1XP_038942910.1  synergin gamma isoform X13

    Conserved Domains (2) summary
    cd00052
    Location:235286
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30331
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  11. XM_039086978.1XP_038942906.1  synergin gamma isoform X9

    Conserved Domains (2) summary
    cd00052
    Location:235286
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30331
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  12. XM_039086979.1XP_038942907.1  synergin gamma isoform X10

    Conserved Domains (2) summary
    cd00052
    Location:235286
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30331
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  13. XM_039086980.1XP_038942908.1  synergin gamma isoform X11

    Related
    ENSRNOP00000070454.2, ENSRNOT00000079418.2
    Conserved Domains (2) summary
    cd00052
    Location:235286
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30331
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RNA

  1. XR_005489958.1 RNA Sequence

  2. XR_005489959.1 RNA Sequence

Support Center