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Gnpat glyceronephosphate O-acyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 84470, updated on 4-Jan-2025

Summary

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Official Symbol
Gnpatprovided by RGD
Official Full Name
glyceronephosphate O-acyltransferaseprovided by RGD
Primary source
RGD:620179
See related
EnsemblRapid:ENSRNOG00000019205 AllianceGenome:RGD:620179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable glycerone-phosphate O-acyltransferase activity. Involved in several processes, including response to fatty acid; response to nutrient; and response to starvation. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Orthologous to human GNPAT (glyceronephosphate O-acyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 225.6), Muscle (RPKM 219.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gnpat in Genome Data Viewer
Location:
19q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (69719707..69746244)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (52822326..52848872)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57614813..57640524)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 43 Neighboring gene tripartite motif-containing 67 Neighboring gene 40S small subunit processome assembly factor 1 Neighboring gene exocyst complex component 8 Neighboring gene SprT-like N-terminal domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment. Bates EJ, et al. Biochem J, 1979 Sep 15. PMID 518562, Free PMC Article
  2. Studies of dihydroxyacetone phosphate acyltransferase in rat small intestine. Subcellular localization and effect of partially hydrogenated fish oil and clofibrate. Ruyter B, et al. Biochem J, 1992 Mar 1. PMID 1546971, Free PMC Article
  3. Effect of 3- and 4-thia-substituted fatty acids on glycerolipid metabolism and mitochondrial beta-oxidation in rat liver. Skorve J, et al. Biochem Pharmacol, 1990 Nov 1. PMID 2242030
  4. Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum. Teigler A, et al. Hum Mol Genet, 2009 Jun 1. PMID 19270340, Free PMC Article
  5. Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids. Liu D, et al. J Lipid Res, 2005 Apr. PMID 15687349

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables catalytic activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerone-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerone-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerone-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerone-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cerebellum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ether lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ether lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ether lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ether lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerophospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within membrane organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myelination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within paranodal junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within synapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dihydroxyacetone phosphate acyltransferase
Names
DAP-AT
DHAP-AT
acyl-CoA:dihydroxyacetonephosphate acyltransferase
acyl-CoA:dihydroxyacetonephosphateacyltransferase
glycerone-phosphate O-acyltransferase
NP_445862.1
XP_038953970.2
XP_038953971.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053410.2 → NP_445862.1  dihydroxyacetone phosphate acyltransferase

    See identical proteins and their annotated locations for NP_445862.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    Q9ES71
    UniProtKB/TrEMBL
    A0A8I5YBP7, A6KJ21
    Related
    ENSRNOP00000106897.1, ENSRNOT00000167276.1
    Conserved Domains (1) summary
    cd07993
    Location:133 → 338
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    69719707..69746244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098043.2 → XP_038953971.1  dihydroxyacetone phosphate acyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBP7
    Related
    ENSRNOP00000026617.5, ENSRNOT00000026617.8
    Conserved Domains (2) summary
    cd07993
    Location:83 → 288
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
    PTZ00374
    Location:17 → 474
    PTZ00374; dihydroxyacetone phosphate acyltransferase; Provisional

  2. XM_039098042.2 → XP_038953970.2  dihydroxyacetone phosphate acyltransferase isoform X1

    UniProtKB/TrEMBL
    A6KJ22
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES71.1 GenPept UniProtKB/Swiss-Prot:Q9ES71

Gene LinkOut

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