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MAP3K21 mitogen-activated protein kinase kinase kinase 21 [ Homo sapiens (human) ]

Gene ID: 84451, updated on 4-May-2020

Summary

Official Symbol
MAP3K21provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 21provided by HGNC
Primary source
HGNC:HGNC:29798
See related
Ensembl:ENSG00000143674 MIM:614793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLK4; dJ862P8.3
Expression
Broad expression in testis (RPKM 6.4), kidney (RPKM 5.7) and 21 other tissues See more
Orthologs

Genomic context

See MAP3K21 in Genome Data Viewer
Location:
1q42.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (233327724..233385148)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (233463514..233520894)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985361 Neighboring gene nucleoside-triphosphatase, cancer-related Neighboring gene pecanex 2 Neighboring gene ribosomal protein S7 pseudogene 3 Neighboring gene RNA, U4 small nuclear 77, pseudogene Neighboring gene microRNA 4427 Neighboring gene potassium two pore domain channel subfamily K member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of periodontal pathogen colonization.
NHGRI GWA Catalog
Genome-wide meta-analysis for severe diabetic retinopathy.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1804

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 21
Names
mitogen-activated protein kinase kinase kinase MLK4
mixed lineage kinase 4
NP_115811.2
XP_011542607.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032435.3NP_115811.2  mitogen-activated protein kinase kinase kinase 21

    See identical proteins and their annotated locations for NP_115811.2

    Status: VALIDATED

    Source sequence(s)
    AJ311798, AL133380
    Consensus CDS
    CCDS1598.1
    UniProtKB/Swiss-Prot
    Q5TCX8
    UniProtKB/TrEMBL
    A0A1W2PKR9
    Related
    ENSP00000355583.3, ENST00000366624.8
    Conserved Domains (2) summary
    cd12058
    Location:4297
    SH3_MLK4; Src Homology 3 domain of Mixed Lineage Kinase 4
    cl21453
    Location:129401
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    233327724..233385148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544305.2XP_011542607.1  mitogen-activated protein kinase kinase kinase 21 isoform X1

    Conserved Domains (3) summary
    smart00219
    Location:124398
    TyrKc; Tyrosine kinase, catalytic domain
    cd12058
    Location:4297
    SH3_MLK4; Src Homology 3 domain of Mixed Lineage Kinase 4
    cl21453
    Location:129401
    PKc_like; Protein Kinases, catalytic domain
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