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NIP6;1 NOD26-like intrinsic protein 6;1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844415, updated on 19-Feb-2025

Summary

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Official Symbol
NIP6;1
Official Full Name
NOD26-like intrinsic protein 6;1
Primary source
TAIR:AT1G80760
Locus tag
AT1G80760
See related
Araport:AT1G80760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATNIP6; F23A5.11; F23A5_11; NIP6; NLM7; NOD26-like intrinsic protein 6;1
Summary
Encodes a protein with boron transporter activity. It helps to preferentially direct boron to young developing tissues in the shoot, such as immature leaves, under low boron conditions. This boron channel appears to be impermeable to water, unlike the closely related NIP5;1 boron transporter. This protein also allows the transport of glycerol, urea, and formimide but not larger uncharged solutes such as arabitol and sucrose when it is expressed heterologously.
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Genomic context

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See NIP6;1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (30350539..30352208, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene chromomethylase 1 Neighboring gene Transcription factor TFIIIC, tau55-related protein Neighboring gene Ribosomal protein L30/L7 family protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NIP6;1 is involved in xylem-phloem transfer of boric acid at the nodal regions and the water-tight property of NIP6;1 is important for this function.
    Title: NIP6;1 is a boric acid channel for preferential transport of boron to growing shoot tissues in Arabidopsis.
  2. Nodulin26-like Intrinsic Proteins (NIPs) AtNIP5;1 and AtNIP6;1 from Arabidopsis thaliana are bi-directional As(III) channels [Nodulin26-like Intrinsic Proteins (NIPs)] [AtNIP6;1]
    Title: A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3 across membranes.
  3. Data show that alanine residue of water-impermeable glyceroporins (AtNIP6;1) in helix 2 position (H2) can predict the transport profile for water and glycerol.
    Title: Distinct transport selectivity of two structural subclasses of the nodulin-like intrinsic protein family of plant aquaglyceroporin channels.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_106724.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables borate channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables urea transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables water channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables water transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within borate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to boron-containing substance levels IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
NOD26-like intrinsic protein 6;1
NP_178191.1
  • NOD26-like intrinsic protein 6;1 (NIP6;1); CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: NOD26-like intrinsic protein 5;1 (TAIR:AT4G10380.1); Has 10266 Blast hits to 10221 proteins in 2131 species: Archae - 103; Bacteria - 5136; Metazoa - 1354; Fungi - 440; Plants - 2031; Viruses - 2; Other Eukaryotes - 1200 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    30350539..30352208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106724.3 → NP_178191.1  NOD26-like intrinsic protein 6;1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178191.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5PP68, Q9SAI4
    UniProtKB/TrEMBL
    A0A5S9WW53, A0A654EQT6
    Conserved Domains (1) summary
    PLN00026
    Location:1 → 305
    PLN00026; aquaporin NIP; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SAI4.1

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