VHA-A vacuolar ATP synthase subunit A [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: VHA-A
Gene description: vacuolar ATP synthase subunit A
Primary source: Araport:AT1G78900
Locus tag: AT1G78900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: vacuolar ATP synthase subunit A
Summary: Encodes catalytic subunit A of the vacuolar ATP synthase. Mutants are devoid of vacuolar ATPase activity as subunit A is encoded only by this gene and show strong defects in male gametophyte development and in Golgi stack morphology.
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Genomic context

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Location:: chromosome: 1

Exon count:: 20

Sequence:: Chromosome: 1; NC_003070.9 (29660088..29665078)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Total VHA-A transcript and protein, together with levels of the truncated variant, were induced by copper. The absence of a genomic sequence representing the truncated variant suggests a RNA editing event causing the production of the truncated VHA-A.
Title: Intracellular localization and induction of a dynamic RNA-editing event of macro-algal V-ATPase subunit A (VHA-A) in response to copper.
oxidative inhibition was unaffected in plants expressing VHA-A C279S and VHA-A C535S, indicating that disulfide bridges involving these cysteine residues are not essential for oxidative inhibition
Title: Regulation of the V-type ATPase by redox modulation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001036222.3

Supported by ESTs:

NM_106539.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast envelope	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
part_of proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	HDA more info	PubMed
located_in vacuole	HDA more info	PubMed

General protein information

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Preferred Names: vacuolar ATP synthase subunit A

NP_001031299.1

vacuolar ATP synthase subunit A (VHA-A); FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, proton-transporting ATPase activity, rotational mechanism, ATP binding; INVOLVED IN: response to salt stress, proton transport, Golgi organization, pollen development; LOCATED IN: in 8 components; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, F1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR018118), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit A (InterPro:IPR005725); BEST Arabidopsis thaliana protein match is: ATP synthase alpha/beta family protein (TAIR:AT5G08670.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_178011.1

vacuolar ATP synthase subunit A (VHA-A); FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, proton-transporting ATPase activity, rotational mechanism, ATP binding; INVOLVED IN: response to salt stress, proton transport, Golgi organization, pollen development; LOCATED IN: in 8 components; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR018118), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, V1 complex, subunit A (InterPro:IPR005725), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194); BEST Arabidopsis thaliana protein match is: ATP synthase alpha/beta family protein (TAIR:AT5G08670.1); Has 40508 Blast hits to 38748 proteins in 9967 species: Archae - 874; Bacteria - 22679; Metazoa - 1366; Fungi - 853; Plants - 8095; Viruses - 0; Other Eukaryotes - 6641 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

29660088..29665078

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_106539.6 → NP_178011.1 vacuolar ATP synthase subunit A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_178011.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23654

UniProtKB/TrEMBL

A0A178W720, A0A384LM33, Q0WLF6

Conserved Domains (1) summary

TIGR01042
Location:20 → 611

V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
NM_001036222.3 → NP_001031299.1 vacuolar ATP synthase subunit A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031299.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23654

UniProtKB/TrEMBL

A0A178W720, A0A384LM33, Q0WLF6

Conserved Domains (1) summary

TIGR01042
Location:20 → 611

V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit