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Robo2 roundabout guidance receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84409, updated on 19-Apr-2019

Summary

Official Symbol
Robo2provided by RGD
Official Full Name
roundabout guidance receptor 2provided by RGD
Primary source
RGD:620167
See related
Ensembl:ENSRNOG00000029598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
repulsive axon guidance receptor for the slit protein ligands; plays a role in axon guidance and repulsion [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 136.1), Lung (RPKM 47.8) and 8 other tissues See more
Orthologs

Genomic context

See Robo2 in Genome Data Viewer
Location:
11p11
Exon count:
32
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (11062866..12618793, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (14733231..16280429, complement)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene roundabout guidance receptor 1 Neighboring gene uncharacterized LOC108352378 Neighboring gene uncharacterized LOC102551586 Neighboring gene uncharacterized LOC108352380 Neighboring gene similar to CG30497-PA, isoform A Neighboring gene nuclease-sensitive element-binding protein 1-like Neighboring gene eukaryotic translation initiation factor 4E-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
axon guidance receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
Roundabout signaling pathway IEA
Inferred from Electronic Annotation
more info
 
aorta development ISO
Inferred from Sequence Orthology
more info
PubMed 
aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
apoptotic process involved in luteolysis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process involved in luteolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance ISO
Inferred from Sequence Orthology
more info
PubMed 
axon midline choice point recognition ISO
Inferred from Sequence Orthology
more info
PubMed 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
brain development ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
PubMed 
kidney development IEA
Inferred from Electronic Annotation
more info
 
metanephros development ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of negative chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
olfactory bulb interneuron development ISO
Inferred from Sequence Orthology
more info
PubMed 
outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of Notch signaling pathway involved in heart induction ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
PubMed 
spinal cord development IEP
Inferred from Expression Pattern
more info
PubMed 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
PubMed 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
axolemma IEA
Inferred from Electronic Annotation
more info
 
axolemma ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
roundabout homolog 2
Names
roundabout 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032106.2NP_115289.1  roundabout homolog 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AABR07033224, AF182037
    UniProtKB/TrEMBL
    Q9QZI3
    Related
    ENSRNOP00000070966.1, ENSRNOT00000088878.1
    Conserved Domains (6) summary
    cd00096
    Location:438504
    Ig; Immunoglobulin domain
    cd05726
    Location:331420
    Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
    smart00410
    Location:427507
    IG_like; Immunoglobulin like
    cd00063
    Location:524617
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:228313
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:140224
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    11062866..12618793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598080.1XP_017453569.1  roundabout homolog 2 isoform X3

    Related
    ENSRNOP00000061003.3, ENSRNOT00000065748.3
  2. XM_008768537.2XP_008766759.2  roundabout homolog 2 isoform X2

  3. XM_017598079.1XP_017453568.1  roundabout homolog 2 isoform X1

  4. XM_017598083.1XP_017453572.1  roundabout homolog 2 isoform X7

  5. XM_008768538.2XP_008766760.2  roundabout homolog 2 isoform X5

  6. XM_017598084.1XP_017453573.1  roundabout homolog 2 isoform X8

  7. XM_017598082.1XP_017453571.1  roundabout homolog 2 isoform X6

  8. XM_008768539.2XP_008766761.2  roundabout homolog 2 isoform X9

  9. XM_017598081.1XP_017453570.1  roundabout homolog 2 isoform X4

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    12554755..13062027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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