Il12a interleukin 12A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il12aprovided by RGD
Official Full Name: interleukin 12Aprovided by RGD
Primary source: RGD:620562
See related: Ensembl:ENSRNOG00000009468 AllianceGenome:RGD:620562
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine binding activity; interleukin-12 receptor binding activity; and protein heterodimerization activity. Predicted to contribute to cytokine activity and growth factor activity. Involved in response to granulocyte colony-stimulating factor. Predicted to be located in cell surface and cytoplasm. Predicted to be part of interleukin-12 complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Thymus (RPKM 41.7), Uterus (RPKM 24.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (155275734..155282997)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (152965769..152973035)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (165076945..165083996)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that endogenous interleukins IL-27 and IL-35 (Ebi3 and Il-12p35 subunits) had inflammatory roles and insulin like growth factor -1 (IGF-1) had no effect.
Title: The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
contributes_to cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
contributes_to growth factor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-12 beta subunit binding	ISO Inferred from Sequence Orthology more info
enables interleukin-12 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-12 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-27 binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T-helper 1 cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-12-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mononuclear cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in response to granulocyte colony-stimulating factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of interleukin-12 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of interleukin-12 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-12 subunit alpha

Names: CLMF p35; IL-12 subunit p35; IL-12A; cytotoxic lymphocyte maturation factor 35 kDa subunit; interleukin 12 p35 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053390.1 → NP_445842.1 interleukin-12 subunit alpha precursor

See identical proteins and their annotated locations for NP_445842.1

Status: PROVISIONAL

Source sequence(s)

AF177031

UniProtKB/Swiss-Prot

Q9R103

UniProtKB/TrEMBL

A6J5M3, G3V780

Related

ENSRNOP00000012832.1, ENSRNOT00000012831.5

Conserved Domains (1) summary

pfam03039
Location:17 → 215

IL12; Interleukin-12 alpha subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

155275734..155282997

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103267.2 → XP_038959195.1 interleukin-12 subunit alpha isoform X1

Conserved Domains (1) summary

pfam03039
Location:2 → 166

IL12; Interleukin-12 alpha subunit