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NCK2 NCK adaptor protein 2 [ Homo sapiens (human) ]

Gene ID: 8440, updated on 23-Nov-2021

Summary

Official Symbol
NCK2provided by HGNC
Official Full Name
NCK adaptor protein 2provided by HGNC
Primary source
HGNC:HGNC:7665
See related
Ensembl:ENSG00000071051 MIM:604930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRB4; NCKbeta
Summary
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 14.7), spleen (RPKM 14.6) and 25 other tissues See more
Orthologs
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Genomic context

See NCK2 in Genome Data Viewer
Location:
2q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (105744649..105894274)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (106361369..106510728)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2946 Neighboring gene uncharacterized LOC107985929 Neighboring gene uncharacterized LOC105373530 Neighboring gene uncharacterized LOC105373531

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
GeneReviews: Not available
NCK2 is significantly associated with opiates addiction in African-origin men.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of NCK adaptor protein 2 (NCK2) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytoskeletal anchor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables signaling receptor complex adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
involved_in ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in immunological synapse formation IEA
Inferred from Electronic Annotation
more info
 
involved_in lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of PERK-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of epidermal growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
involved_in signal complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytoplasmic protein NCK2
Names
SH2/SH3 adaptor protein NCK-beta
growth factor receptor-bound protein 4
noncatalytic region of tyrosine kinase, beta

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004720.3NP_001004720.1  cytoplasmic protein NCK2 isoform A

    See identical proteins and their annotated locations for NP_001004720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (A).
    Source sequence(s)
    AC009505, BC000103, DB456958
    Consensus CDS
    CCDS33266.1
    UniProtKB/Swiss-Prot
    O43639
    UniProtKB/TrEMBL
    A0A0S2Z4M6
    Related
    ENSP00000377018.2, ENST00000393349.2
    Conserved Domains (4) summary
    cd10409
    Location:283380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:259
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
  2. NM_001004722.4NP_001004722.1  cytoplasmic protein NCK2 isoform B

    See identical proteins and their annotated locations for NP_001004722.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform B) is shorter and has a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC009505, AC010978, BG480643
    UniProtKB/TrEMBL
    E7ERP6
    Related
    ENSP00000410428.2, ENST00000451463.6
    Conserved Domains (1) summary
    cl17036
    Location:259
    SH3; Src Homology 3 domain superfamily
  3. NM_003581.5NP_003572.2  cytoplasmic protein NCK2 isoform A

    See identical proteins and their annotated locations for NP_003572.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1 and 2 both encode isoform A.
    Source sequence(s)
    AC009505, AC010978, BC007195
    Consensus CDS
    CCDS33266.1
    UniProtKB/Swiss-Prot
    O43639
    UniProtKB/TrEMBL
    A0A0S2Z4M6
    Related
    ENSP00000233154.4, ENST00000233154.9
    Conserved Domains (4) summary
    cd10409
    Location:283380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:259
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    105744649..105894274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005105.1XP_016860594.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/Swiss-Prot
    O43639
    UniProtKB/TrEMBL
    A0A0S2Z4M6
    Conserved Domains (4) summary
    cd10409
    Location:283380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:259
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
  2. XM_011511991.3XP_011510293.1  cytoplasmic protein NCK2 isoform X1

    See identical proteins and their annotated locations for XP_011510293.1

    UniProtKB/Swiss-Prot
    O43639
    UniProtKB/TrEMBL
    A0A0S2Z4M6
    Conserved Domains (4) summary
    cd10409
    Location:283380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:259
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
  3. XM_017005103.1XP_016860592.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/Swiss-Prot
    O43639
    UniProtKB/TrEMBL
    A0A0S2Z4M6
    Conserved Domains (4) summary
    cd10409
    Location:283380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:259
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
  4. XM_006712797.3XP_006712860.1  cytoplasmic protein NCK2 isoform X1

    See identical proteins and their annotated locations for XP_006712860.1

    UniProtKB/Swiss-Prot
    O43639
    UniProtKB/TrEMBL
    A0A0S2Z4M6
    Conserved Domains (4) summary
    cd10409
    Location:283380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:259
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
  5. XM_017005104.1XP_016860593.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/Swiss-Prot
    O43639
    UniProtKB/TrEMBL
    A0A0S2Z4M6
    Conserved Domains (4) summary
    cd10409
    Location:283380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:259
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
  6. XM_011511992.2XP_011510294.2  cytoplasmic protein NCK2 isoform X2

    UniProtKB/TrEMBL
    E7ERP6
    Conserved Domains (1) summary
    cl17036
    Location:259
    SH3; Src Homology 3 domain superfamily
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