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Tcf4 transcription factor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84382, updated on 11-Jun-2025
Official Symbol
Tcf4provided by RGD
Official Full Name
transcription factor 4provided by RGD
Primary source
RGD:69271
See related
Ensembl:ENSRNOG00000012405 AllianceGenome:RGD:69271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables bHLH transcription factor binding activity and double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF7L2 complex. Predicted to be active in chromatin. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Lynch syndrome; and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in Heart (RPKM 220.1), Brain (RPKM 214.5) and 9 other tissues See more
Orthologs
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See Tcf4 in Genome Data Viewer
Location:
18q12.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (65216840..65563186)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (62941739..63288126)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (65285320..65507983)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348808 Neighboring gene uncharacterized LOC108348809 Neighboring gene uncharacterized LOC134482985 Neighboring gene coiled-coil domain containing 68

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables TFIIB-class transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within endothelial cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-DNA complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
 
part_of beta-catenin-TCF7L2 complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
transcription factor 4
Names
ITF-2
R8f DNA-binding protein
RITF-2
SEF-2
SL3-3 enhancer factor 2
TCF-4
immunoglobulin transcription factor 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001437064.1NP_001423993.1  transcription factor 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JWU7
  2. NM_001437065.1NP_001423994.1  transcription factor 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JWU7
  3. NM_001437066.1NP_001423995.1  transcription factor 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JWU7
  4. NM_001437067.1NP_001423996.1  transcription factor 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q62655, Q99N33
  5. NM_001437068.1NP_001423997.1  transcription factor 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q62655, Q99N33
  6. NM_001437069.1NP_001423998.1  transcription factor 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q62655, Q99N33
  7. NM_001437070.1NP_001423999.1  transcription factor 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q62655, Q99N33
  8. NM_001437071.1NP_001424000.1  transcription factor 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q62655, Q99N33
  9. NM_001437074.1NP_001424003.1  transcription factor 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q62655, Q99N33
  10. NM_001437077.1NP_001424006.1  transcription factor 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JXN5
  11. NM_001437079.1NP_001424008.1  transcription factor 4 isoform 12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JXN5
  12. NM_001437083.1NP_001424012.1  transcription factor 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A561, A0A8I6GLJ0, A6IXY9
  13. NM_001437085.1NP_001424014.1  transcription factor 4 isoform 14

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A561
  14. NM_001437087.1NP_001424016.1  transcription factor 4 isoform 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A561
  15. NM_001437089.1NP_001424018.1  transcription factor 4 isoform 16

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A561
  16. NM_001437091.1NP_001424020.1  transcription factor 4 isoform 17

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A561
  17. NM_001437093.1NP_001424022.1  transcription factor 4 isoform 18

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A561
  18. NM_001437095.1NP_001424024.1  transcription factor 4 isoform 19

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A561
  19. NM_001437096.1NP_001424025.1  transcription factor 4 isoform 20

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A561
  20. NM_001437097.1NP_001424026.1  transcription factor 4 isoform 21

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JWU7, A6IXY6, F1LQ90
  21. NM_001437098.1NP_001424027.1  transcription factor 4 isoform 21

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JWU7, A6IXY6, F1LQ90
  22. NM_001437099.1NP_001424028.1  transcription factor 4 isoform 21

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JWU7, A6IXY6, F1LQ90
  23. NM_001437100.1NP_001424029.1  transcription factor 4 isoform 22

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q62655, Q99N33
    UniProtKB/TrEMBL
    A6IXY7
  24. NM_001437101.1NP_001424030.1  transcription factor 4 isoform 22

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q62655, Q99N33
    UniProtKB/TrEMBL
    A6IXY7
  25. NM_053369.3NP_445821.2  transcription factor 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2JWU7
    Related
    ENSRNOP00000070021.2, ENSRNOT00000081797.3
    Conserved Domains (2) summary
    COG5422
    Location:81295
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:555639
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    65216840..65563186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277625.1XP_063133695.1  transcription factor 4 isoform X13

  2. XM_063277624.1XP_063133694.1  transcription factor 4 isoform X12

  3. XM_039097159.2XP_038953087.1  transcription factor 4 isoform X1

    Related
    ENSRNOP00000106951.1, ENSRNOT00000126184.1
    Conserved Domains (2) summary
    COG5422
    Location:135296
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:560644
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  4. XM_039097169.2XP_038953097.1  transcription factor 4 isoform X10

    Conserved Domains (2) summary
    COG5422
    Location:111272
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:536620
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  5. XM_063277623.1XP_063133693.1  transcription factor 4 isoform X11

  6. XM_063277626.1XP_063133696.1  transcription factor 4 isoform X14

  7. XM_039097157.2XP_038953085.1  transcription factor 4 isoform X1

    Conserved Domains (2) summary
    COG5422
    Location:135296
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:560644
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  8. XM_063277622.1XP_063133692.1  transcription factor 4 isoform X10

  9. XM_063277621.1XP_063133691.1  transcription factor 4 isoform X9

  10. XM_063277618.1XP_063133688.1  transcription factor 4 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JWU7
  11. XM_063277617.1XP_063133687.1  transcription factor 4 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JWU7
  12. XM_063277615.1XP_063133685.1  transcription factor 4 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JWU7
  13. XM_063277616.1XP_063133686.1  transcription factor 4 isoform X4

  14. XM_063277620.1XP_063133690.1  transcription factor 4 isoform X8

  15. XM_039097158.2XP_038953086.1  transcription factor 4 isoform X1

    Conserved Domains (2) summary
    COG5422
    Location:135296
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:560644
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  16. XM_063277619.1XP_063133689.1  transcription factor 4 isoform X7

  17. XM_063277614.1XP_063133684.1  transcription factor 4 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JWU7
  18. XM_039097170.2XP_038953098.1  transcription factor 4 isoform X10

    UniProtKB/Swiss-Prot
    Q62655, Q99N33
    UniProtKB/TrEMBL
    A6IXY7
    Conserved Domains (2) summary
    COG5422
    Location:111272
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:536620
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  19. XM_039097160.2XP_038953088.1  transcription factor 4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWU7, A6IXY6, F1LQ90
    Conserved Domains (2) summary
    COG5422
    Location:135296
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:560644
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  20. XM_039097177.2XP_038953105.2  transcription factor 4 isoform X19

    UniProtKB/TrEMBL
    A0A0G2JXN5, A6IXY8
    Related
    ENSRNOP00000020431.9, ENSRNOT00000020431.9
  21. XM_039097173.2XP_038953101.1  transcription factor 4 isoform X15

    Related
    ENSRNOP00000096285.2, ENSRNOT00000114956.2
    Conserved Domains (2) summary
    COG5422
    Location:65226
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:490574
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  22. XM_063277627.1XP_063133697.1  transcription factor 4 isoform X17

  23. XM_039097174.2XP_038953102.1  transcription factor 4 isoform X16

    UniProtKB/Swiss-Prot
    Q62655, Q99N33
    Conserved Domains (2) summary
    COG5422
    Location:64225
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:489573
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  24. XM_039097176.2XP_038953104.1  transcription factor 4 isoform X18

    UniProtKB/Swiss-Prot
    Q62655, Q99N33
    Conserved Domains (2) summary
    COG5422
    Location:64225
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:485569
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  25. XM_063277628.1XP_063133698.1  transcription factor 4 isoform X20

  26. XM_039097184.2XP_038953112.1  transcription factor 4 isoform X19

    UniProtKB/TrEMBL
    A0A0G2JXN5, A6IXY8
    Conserved Domains (2) summary
    COG5422
    Location:6167
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:431515
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  27. XM_039097185.2XP_038953113.1  transcription factor 4 isoform X19

    UniProtKB/TrEMBL
    A0A0G2JXN5, A6IXY8
    Related
    ENSRNOP00000070343.3, ENSRNOT00000080844.3
    Conserved Domains (2) summary
    COG5422
    Location:6167
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd18945
    Location:431515
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  28. XM_063277629.1XP_063133699.1  transcription factor 4 isoform X20

  29. XM_039097186.2XP_038953114.1  transcription factor 4 isoform X21

    Related
    ENSRNOP00000099053.1, ENSRNOT00000144722.1
    Conserved Domains (1) summary
    cd18945
    Location:401485
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  30. XM_039097189.2XP_038953117.1  transcription factor 4 isoform X24

    Related
    ENSRNOP00000087117.1, ENSRNOT00000118039.2
    Conserved Domains (1) summary
    cd18945
    Location:397481
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  31. XM_039097187.2XP_038953115.1  transcription factor 4 isoform X23

    Conserved Domains (1) summary
    cd18945
    Location:400484
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  32. XM_063277630.1XP_063133700.1  transcription factor 4 isoform X25

  33. XM_039097188.2XP_038953116.1  transcription factor 4 isoform X22

    Conserved Domains (1) summary
    cd18945
    Location:400484
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  34. XM_039097190.2XP_038953118.1  transcription factor 4 isoform X26

    Conserved Domains (1) summary
    cd18945
    Location:396480
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
  35. XM_063277631.1XP_063133701.1  transcription factor 4 isoform X27

  36. XM_039097191.2XP_038953119.1  transcription factor 4 isoform X28

    Conserved Domains (1) summary
    cd18945
    Location:345429
    bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins