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HOOK3 hook microtubule tethering protein 3 [ Homo sapiens (human) ]

Gene ID: 84376, updated on 11-Sep-2019

Summary

Official Symbol
HOOK3provided by HGNC
Official Full Name
hook microtubule tethering protein 3provided by HGNC
Primary source
HGNC:HGNC:23576
See related
Ensembl:ENSG00000168172 MIM:607825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HK3
Summary
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in thyroid (RPKM 6.6), fat (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See HOOK3 in Genome Data Viewer
Location:
8p11.21
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (42896978..43030535)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (42752033..42885682)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 170 Neighboring gene RNA, 7SL, cytoplasmic 806, pseudogene Neighboring gene microRNA 4469 Neighboring gene RNA, U1 small nuclear 124, pseudogene Neighboring gene farnesyltransferase, CAAX box, alpha Neighboring gene protein O-mannose kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: FNTA

Homology

Clone Names

  • FLJ31058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynactin binding IDA
Inferred from Direct Assay
more info
PubMed 
dynein intermediate chain binding IDA
Inferred from Direct Assay
more info
PubMed 
dynein light chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
interkinetic nuclear migration ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule anchoring at centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
protein localization to centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
FHF complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with HOPS complex IDA
Inferred from Direct Assay
more info
PubMed 
centriolar satellite IEA
Inferred from Electronic Annotation
more info
 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
pericentriolar material ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein Hook homolog 3
Names
h-hook3
hHK3
hook homolog 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032410.4NP_115786.1  protein Hook homolog 3

    See identical proteins and their annotated locations for NP_115786.1

    Status: VALIDATED

    Source sequence(s)
    AC110275, BC048304, BC056146, BM716064
    Consensus CDS
    CCDS6139.1
    UniProtKB/Swiss-Prot
    Q86VS8
    Related
    ENSP00000305699.3, ENST00000307602.9
    Conserved Domains (1) summary
    pfam05622
    Location:12710
    HOOK; HOOK protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    42896978..43030535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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