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S1 sigma-1 protein [ Mammalian orthoreovirus 3 ]

Gene ID: 8437025, updated on 18-Aug-2023

Summary

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Gene symbol
S1
Gene description
sigma-1 protein
Locus tag
MoV-3mpc04sS1_gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mammalian orthoreovirus 3 (serotype: 3, isolate: MPC/04, nat-host: masked palm civet)
Lineage
Viruses; dsRNA viruses; Reoviridae; Spinareovirinae; Orthoreovirus
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Genomic context

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Location:
segment: S1
Sequence:
NC_013231.1 (1..1368)

NC_013231.1Genomic Context describing neighboring genes Neighboring gene minor capsid cell attachment protein sigma1s

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_013231.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles. Lee CH, et al. mBio, 2021 Aug 31. PMID 34225484, Free PMC Article
  2. Optimum length and flexibility of reovirus attachment protein σ1 are required for efficient viral infection. Bokiej M, et al. J Virol, 2012 Oct. PMID 22811534, Free PMC Article
  3. Protein Mismatches Caused by Reassortment Influence Functions of the Reovirus Capsid. Thete D, et al. J Virol, 2018 Oct 15. PMID 30068646, Free PMC Article
  4. Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis. Shmulevitz M, et al. J Virol, 2012 Jul. PMID 22532697, Free PMC Article
  5. Reovirus hemagglutinin mRNA codes for two polypeptides in overlapping reading frames. Ernst H, et al. Proc Natl Acad Sci U S A, 1985 Jan. PMID 3855548, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reovirus Nonstructural Protein sigmaNS Recruits Viral RNA to Replication Organelles.
    Title: Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles.
  2. Importantly, a virus with matching sigma1 and lambda2 displayed a more regulated conversion of infectious subvirion particles (ISPV) to ISVP* than either T3D(F)/T3D(C)S1 or T3D(F)/T3D(C)L2. In addition to identifying new regulators of ISVP* formation, the results highlight that protein mismatches produced by reassortment can alter virus assembly and thereby influence subsequent functions of the virus capsid.
    Title: Protein Mismatches Caused by Reassortment Influence Functions of the Reovirus Capsid.
  3. Optimum length and flexibility of reovirus attachment protein sigma1 are required for efficient viral infection
    Title: Optimum length and flexibility of reovirus attachment protein σ1 are required for efficient viral infection.
  4. Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis.
    Title: Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis.
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General protein information

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Preferred Names
sigma-1 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_013231.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003199424.1 sigma-1 protein [Mammalian orthoreovirus 3]

    See identical proteins and their annotated locations for YP_003199424.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    C9E876, F1D6A4
    Conserved Domains (2) summary
    pfam04582
    Location:1 → 189
    Reo_sigmaC; Reovirus sigma C capsid protein
    pfam01664
    Location:239 → 454
    Reo_sigma1; Reovirus viral attachment protein sigma 1
Nucleotide Protein
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