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NIFK nucleolar protein interacting with the FHA domain of MKI67 [ Homo sapiens (human) ]

Gene ID: 84365, updated on 6-Jan-2019

Summary

Official Symbol
NIFKprovided by HGNC
Official Full Name
nucleolar protein interacting with the FHA domain of MKI67provided by HGNC
Primary source
HGNC:HGNC:17838
See related
Ensembl:ENSG00000155438 MIM:611970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nopp34; MKI67IP
Summary
This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in lymph node (RPKM 19.8), appendix (RPKM 17.9) and 25 other tissues See more
Orthologs

Genomic context

See NIFK in Genome Data Viewer
Location:
2q14.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (121726945..121736927, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (122484521..122494503, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NIFK antisense RNA 1 Neighboring gene ribosomal protein L12 pseudogene 15 Neighboring gene nucleophosmin 1 pseudogene 32 Neighboring gene translin Neighboring gene uncharacterized LOC105373590

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify Nopp34 associated HIV-1 Gag in 293T cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human MKI67 (FHA domain) interacting nucleolar phosphoprotein (MKI67IP) at amino acid residues 188-189 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein-containing complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
rRNA metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
rRNA transcription NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MKI67 FHA domain-interacting nucleolar phosphoprotein
Names
hNIFK
nucleolar phosphoprotein Nopp34
nucleolar protein interacting with the FHA domain of pKi-67

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032390.5NP_115766.3  MKI67 FHA domain-interacting nucleolar phosphoprotein

    See identical proteins and their annotated locations for NP_115766.3

    Status: REVIEWED

    Source sequence(s)
    BC022990, BC024238, BE671589
    Consensus CDS
    CCDS2135.1
    UniProtKB/Swiss-Prot
    Q9BYG3
    Related
    ENSP00000285814.4, ENST00000285814.8
    Conserved Domains (3) summary
    cd12307
    Location:46119
    RRM_NIFK_like; RNA recognition motif in nucleolar protein interacting with the FHA domain of pKI-67 (NIFK) and similar proteins
    pfam12196
    Location:227266
    hNIFK_binding; FHA Ki67 binding domain of hNIFK
    cl25887
    Location:2151
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    121726945..121736927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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