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ARFGAP2 ADP ribosylation factor GTPase activating protein 2 [ Homo sapiens (human) ]

Gene ID: 84364, updated on 21-Dec-2019

Summary

Official Symbol
ARFGAP2provided by HGNC
Official Full Name
ADP ribosylation factor GTPase activating protein 2provided by HGNC
Primary source
HGNC:HGNC:13504
See related
Ensembl:ENSG00000149182 MIM:606908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRZ; ZFP289; ZNF289; NBLA10535
Expression
Ubiquitous expression in skin (RPKM 24.0), brain (RPKM 23.0) and 25 other tissues See more
Orthologs

Genomic context

See ARFGAP2 in Genome Data Viewer
Location:
11p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (47164298..47177125, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47185849..47199054, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 49 Neighboring gene ATPase Asna1 pseudogene Neighboring gene uncharacterized LOC107984329 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene microRNA 6745 Neighboring gene ribosomal protein S20 pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies ARFGAP2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14576, FLJ26000

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
COPI coating of Golgi vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ADP-ribosylation factor GTPase-activating protein 2
Names
GTPase-activating protein ZNF289
zinc finger protein 289, ID1 regulated

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242832.1NP_001229761.1  ADP-ribosylation factor GTPase-activating protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001229761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK301785, BC030148, BM827445, CD366084
    Consensus CDS
    CCDS73283.1
    UniProtKB/Swiss-Prot
    Q8N6H7
    UniProtKB/TrEMBL
    G5E9L0
    Related
    ENSP00000400226.3, ENST00000426335.6
    Conserved Domains (2) summary
    PLN03114
    Location:1443
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11117
    ArfGap; Putative GTPase activating protein for Arf
  2. NM_032389.6NP_115765.2  ADP-ribosylation factor GTPase-activating protein 2 isoform 1

    See identical proteins and their annotated locations for NP_115765.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090589
    Consensus CDS
    CCDS7926.1
    UniProtKB/Swiss-Prot
    Q8N6H7
    Related
    ENSP00000434442.1, ENST00000524782.6
    Conserved Domains (3) summary
    PLN03114
    Location:1471
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11117
    ArfGap; Putative GTPase activating protein for Arf
    cl23720
    Location:227299
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    47164298..47177125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520405.2XP_011518707.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X6

    Conserved Domains (2) summary
    PLN03114
    Location:1457
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11117
    ArfGap; Putative GTPase activating protein for Arf
  2. XM_006718346.2XP_006718409.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X3

    Conserved Domains (3) summary
    PLN03114
    Location:1496
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11117
    ArfGap; Putative GTPase activating protein for Arf
    cl23720
    Location:252324
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. XM_005253166.2XP_005253223.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X1

    Conserved Domains (3) summary
    PLN03114
    Location:1510
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11117
    ArfGap; Putative GTPase activating protein for Arf
    cl23720
    Location:266338
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  4. XM_005253168.3XP_005253225.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X4

    See identical proteins and their annotated locations for XP_005253225.1

    Conserved Domains (3) summary
    PLN03114
    Location:1485
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11117
    ArfGap; Putative GTPase activating protein for Arf
    cl23720
    Location:241313
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  5. XM_017018413.2XP_016873902.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X5

  6. XM_005253167.2XP_005253224.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X2

    Conserved Domains (3) summary
    PLN03114
    Location:1499
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11117
    ArfGap; Putative GTPase activating protein for Arf
    cl23720
    Location:255327
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  7. XM_017018415.2XP_016873904.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X8

  8. XM_017018414.2XP_016873903.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X7

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