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Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 84351, updated on 22-Sep-2022

Summary

Official Symbol
Ikbkbprovided by RGD
Official Full Name
inhibitor of nuclear factor kappa B kinase subunit betaprovided by RGD
Primary source
RGD:621375
See related
Ensembl:ENSRNOG00000019073 AllianceGenome:RGD:621375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IKK2; AIM-1
Summary
Enables ATP binding activity. Contributes to IkappaB kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; response to cholecystokinin; and response to lipopolysaccharide. Located in cytosol and intracellular membrane-bounded organelle. Part of IkappaB kinase complex. Used to study muscular atrophy and pneumonia. Biomarker of Alzheimer's disease; colitis; colon cancer; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast cancer; combined immunodeficiency (multiple); dermatitis; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 138.6), Thymus (RPKM 121.8) and 9 other tissues See more
Orthologs
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Genomic context

See Ikbkb in Genome Data Viewer
Location:
16q12.5
Exon count:
22
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69319487..69373251)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74177233..74230809)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene plasminogen activator, tissue type Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene DNA polymerase beta Neighboring gene dickkopf WNT signaling pathway inhibitor 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to IkappaB kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to IkappaB kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables IkappaB kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables IkappaB kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in I-kappaB phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myosin-light-chain-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cholecystokinin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in skeletal muscle contraction IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CD40 receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of IkappaB kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of IkappaB kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit beta
Names
I-kappa-B kinase 2
I-kappa-B-kinase beta
IKK-B
IKK-beta
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappaB kinase beta
inhibitor of nuclear factor kappa B kinase beta subunit
nuclear factor NF-kappa-B inhibitor kinase beta
serine/threonine protein kinase IKBKB
NP_445807.2
XP_038950795.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053355.3NP_445807.2  inhibitor of nuclear factor kappa-B kinase subunit beta

    See identical proteins and their annotated locations for NP_445807.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000283
    UniProtKB/Swiss-Prot
    Q9QY78
    UniProtKB/TrEMBL
    G3V8H5
    Related
    ENSRNOP00000025851.2, ENSRNOT00000025851.5
    Conserved Domains (4) summary
    cd14038
    Location:20309
    STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
    cd17046
    Location:310390
    Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
    pfam12179
    Location:708742
    IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
    pfam18397
    Location:389663
    IKBKB_SDD; IQBAL scaffold dimerization domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    69319487..69373251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094867.1XP_038950795.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

    Conserved Domains (2) summary
    cd14038
    Location:20309
    STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
    cd17046
    Location:310390
    Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins