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RECK reversion inducing cysteine rich protein with kazal motifs [ Homo sapiens (human) ]

Gene ID: 8434, updated on 18-Nov-2018

Summary

Official Symbol
RECKprovided by HGNC
Official Full Name
reversion inducing cysteine rich protein with kazal motifsprovided by HGNC
Primary source
HGNC:HGNC:11345
See related
Ensembl:ENSG00000122707 MIM:605227; Vega:OTTHUMG00000019898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST15
Summary
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in gall bladder (RPKM 6.7), endometrium (RPKM 6.4) and 24 other tissues See more
Orthologs

Genomic context

See RECK in Genome Data Viewer
Location:
9p13.3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (36036905..36124455)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36036910..36124452)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily S member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily AM member 1 pseudogene Neighboring gene GLI pathogenesis related 2 Neighboring gene calicin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystem (from REACTOME)
    Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystemGlycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactio...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 
coreceptor activity involved in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloendopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blood vessel maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of establishment of blood-brain barrier IEA
Inferred from Electronic Annotation
more info
 
sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vasculature development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Wnt signalosome IEA
Inferred from Electronic Annotation
more info
 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
reversion-inducing cysteine-rich protein with Kazal motifs
Names
membrane-anchored glycoprotein (metastasis and invasion)
suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)
suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs)
suppressor of tumorigenicity 15 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316345.1NP_001303274.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains two alternate exons in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, BC050306
    UniProtKB/TrEMBL
    A8K9D8
    Conserved Domains (2) summary
    pfam03137
    Location:505530
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    pfam14828
    Location:674758
    Amnionless; Amnionless
  2. NM_001316346.1NP_001303275.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, AL138834, BC060806, BX393623, CA431378
    UniProtKB/TrEMBL
    A8K9D8, Q6P9E2
  3. NM_001316347.1NP_001303276.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, BC060806, CA431378, JQ756320
    UniProtKB/TrEMBL
    A8K9D8, Q6P9E2
  4. NM_001316348.1NP_001303277.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, BC060806, CA431378
    UniProtKB/TrEMBL
    A8K9D8, Q6P9E2
  5. NM_021111.2NP_066934.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor

    See identical proteins and their annotated locations for NP_066934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK292653, BC050306, D50406
    Consensus CDS
    CCDS6597.1
    UniProtKB/Swiss-Prot
    O95980
    UniProtKB/TrEMBL
    A8K9D8
    Related
    ENSP00000367202.3, OTTHUMP00000021369, ENST00000377966.3, OTTHUMT00000052409
    Conserved Domains (2) summary
    pfam03137
    Location:633658
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    pfam14828
    Location:802886
    Amnionless; Amnionless

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    36036905..36124455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015208.1XP_016870697.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X2

    Conserved Domains (2) summary
    pfam03137
    Location:505530
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    pfam14828
    Location:674758
    Amnionless; Amnionless
  2. XM_017015207.1XP_016870696.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

  3. XM_017015209.1XP_016870698.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X2

    Conserved Domains (2) summary
    pfam03137
    Location:505530
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    pfam14828
    Location:674758
    Amnionless; Amnionless
  4. XM_017015211.2XP_016870700.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X3

  5. XM_017015210.1XP_016870699.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X2

    Conserved Domains (2) summary
    pfam03137
    Location:505530
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    pfam14828
    Location:674758
    Amnionless; Amnionless
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