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TMEM101 transmembrane protein 101 [ Homo sapiens (human) ]

Gene ID: 84336, updated on 22-Sep-2022

Summary

Official Symbol
TMEM101provided by HGNC
Official Full Name
transmembrane protein 101provided by HGNC
Primary source
HGNC:HGNC:28653
See related
Ensembl:ENSG00000091947 AllianceGenome:HGNC:28653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 12.8), kidney (RPKM 8.2) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM101 in Genome Data Viewer
Location:
17q21.31
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (44011188..44023215, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44863696..44875727, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42088556..42100583, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene peptide YY Neighboring gene N-acetylglutamate synthase Neighboring gene small nucleolar RNA U3 Neighboring gene LSM12 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4251, FLJ23987

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 101
Names
putative NF-kappa-B-activating protein 130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304813.2NP_001291742.1  transmembrane protein 101 isoform b

    See identical proteins and their annotated locations for NP_001291742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure, and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AC023855, AI420766, BC007438, DC393428, DC393490
    UniProtKB/Swiss-Prot
    Q96IK0
    UniProtKB/TrEMBL
    B4DFS4
    Conserved Domains (1) summary
    pfam15111
    Location:1198
    TMEM101; TMEM101 protein family
  2. NM_001304814.2NP_001291743.1  transmembrane protein 101 isoform b

    See identical proteins and their annotated locations for NP_001291743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure, and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AI420766, BC007438, DC344561
    UniProtKB/Swiss-Prot
    Q96IK0
    UniProtKB/TrEMBL
    B4DFS4
    Conserved Domains (1) summary
    pfam15111
    Location:1198
    TMEM101; TMEM101 protein family
  3. NM_032376.4NP_115752.1  transmembrane protein 101 isoform a

    See identical proteins and their annotated locations for NP_115752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AI420766, BC007438
    Consensus CDS
    CCDS11474.1
    UniProtKB/Swiss-Prot
    B2R9N6, Q96IK0
    Related
    ENSP00000206380.3, ENST00000206380.8
    Conserved Domains (1) summary
    pfam15111
    Location:8256
    TMEM101; TMEM101 protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    44011188..44023215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436933.1XP_047292889.1  transmembrane protein 101 isoform X1

    UniProtKB/Swiss-Prot
    B2R9N6
    Related
    ENSP00000468025.1, ENST00000589334.5
  2. XM_047436937.1XP_047292893.1  transmembrane protein 101 isoform X1

    UniProtKB/Swiss-Prot
    B2R9N6
  3. XM_047436936.1XP_047292892.1  transmembrane protein 101 isoform X1

    UniProtKB/Swiss-Prot
    B2R9N6
  4. XM_047436935.1XP_047292891.1  transmembrane protein 101 isoform X1

    UniProtKB/Swiss-Prot
    B2R9N6
  5. XM_047436934.1XP_047292890.1  transmembrane protein 101 isoform X1

    UniProtKB/Swiss-Prot
    B2R9N6
  6. XM_024451006.2XP_024306774.1  transmembrane protein 101 isoform X2

    UniProtKB/TrEMBL
    B4DFS4
    Conserved Domains (1) summary
    pfam15111
    Location:1198
    TMEM101; TMEM101 protein family
  7. XM_047436932.1XP_047292888.1  transmembrane protein 101 isoform X1

    UniProtKB/Swiss-Prot
    B2R9N6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    44863696..44875727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)