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SBH1 sphingoid base hydroxylase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843300, updated on 4-Jul-2019

Summary

Gene symbol
SBH1
Gene description
sphingoid base hydroxylase 1
Primary source
Araport:AT1G69640
Locus tag
AT1G69640
Gene type
protein coding
RNA name
sphingoid base hydroxylase 1
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F24J1.22; sphingoid base hydroxylase 1
Summary
Encodes one of the two redundant sphingoid base hydroxylases (SBH). Involved in sphingolipid trihydroxy long-chain base (4-hydroxysphinganine) biosynthesis. Double mutants of SBHs were dwarfed and not able to progress from vegetative to reproductive growth.

Genomic context

See SBH1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
2
Sequence:
Chromosome: 1; NC_003070.9 (26193618..26195726, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L34 Neighboring gene ncRNA Neighboring gene F-box/RNI-like superfamily protein Neighboring gene TRAF-like family protein Neighboring gene TRAF-like family protein

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

NM_105632.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
sphingosine hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingosine hydroxylase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
photomorphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sphingoid base hydroxylase 1
NP_177122.2
  • sphingoid base hydroxylase 1 (SBH1); CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sphingoid base hydroxylase 2 (TAIR:AT1G14290.1); Has 2400 Blast hits to 2339 proteins in 395 species: Archae - 0; Bacteria - 406; Metazoa - 416; Fungi - 708; Plants - 429; Viruses - 3; Other Eukaryotes - 438 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    26193618..26195726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105632.5NP_177122.2  sphingoid base hydroxylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_177122.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8VYI1
    UniProtKB/TrEMBL
    A0A178W418
    Conserved Domains (2) summary
    COG3000
    Location:93258
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    pfam04116
    Location:99235
    FA_hydroxylase; Fatty acid hydroxylase superfamily
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