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ZNF414 zinc finger protein 414 [ Homo sapiens (human) ]

Gene ID: 84330, updated on 5-Aug-2022

Summary

Official Symbol
ZNF414provided by HGNC
Official Full Name
zinc finger protein 414provided by HGNC
Primary source
HGNC:HGNC:20630
See related
Ensembl:ENSG00000133250 AllianceGenome:HGNC:20630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP414
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 4.4), prostate (RPKM 4.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF414 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8509678..8514167, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8497262..8501751, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8574562..8579051, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene uncharacterized LOC124904633 Neighboring gene myosin IF Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15716

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146175.2NP_001139647.1  zinc finger protein 414 isoform 1

    See identical proteins and their annotated locations for NP_001139647.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092298, AK225034, BC007310, BQ773835, BU621653, DA257941
    Consensus CDS
    CCDS54211.1
    UniProtKB/Swiss-Prot
    Q96IQ9
    Related
    ENSP00000377504.3, ENST00000393927.9
    Conserved Domains (3) summary
    sd00017
    Location:114133
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05104
    Location:294
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    pfam15909
    Location:110204
    zf-C2H2_8; C2H2-type zinc ribbon
  2. NM_032370.3NP_115746.2  zinc finger protein 414 isoform 2

    See identical proteins and their annotated locations for NP_115746.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC092298, AI937020, AK225034, BC007310, BM141801, DA257941
    Consensus CDS
    CCDS12205.1
    UniProtKB/Swiss-Prot
    A8MY94, Q96IQ9
    Related
    ENSP00000255616.7, ENST00000255616.8
    Conserved Domains (2) summary
    sd00017
    Location:114133
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:110204
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    8509678..8514167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    8497262..8501751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)