Format

Send to:

Choose Destination

METTL26 methyltransferase like 26 [ Homo sapiens (human) ]

Gene ID: 84326, updated on 11-Jun-2021

Summary

Official Symbol
METTL26provided by HGNC
Official Full Name
methyltransferase like 26provided by HGNC
Primary source
HGNC:HGNC:14141
See related
Ensembl:ENSG00000130731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JFP2; C16orf13
Expression
Ubiquitous expression in kidney (RPKM 12.8), ovary (RPKM 12.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See METTL26 in Genome Data Viewer
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (634429..636364, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (684430..686305, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RAB40C, member RAS oncogene family Neighboring gene uncharacterized LOC101929280 Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 Neighboring gene uncharacterized LOC100287175 Neighboring gene tRNA-Gly (anticodon CCC) 2-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13114

General protein information

Preferred Names
methyltransferase-like 26
Names
UPF0585 protein C16orf13

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040160.3NP_001035250.1  methyltransferase-like 26 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a longer and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK295628, BU539308, DB499720
    Consensus CDS
    CCDS42091.1
    UniProtKB/Swiss-Prot
    Q96S19
    Related
    ENSP00000440765.2, ENST00000397666.6
    Conserved Domains (1) summary
    cl17173
    Location:4140
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001040161.3NP_001035251.1  methyltransferase-like 26 isoform c

    See identical proteins and their annotated locations for NP_001035251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three exons in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    BC007207
    Consensus CDS
    CCDS32352.1
    UniProtKB/Swiss-Prot
    Q96S19
    Related
    ENSP00000444140.2, ENST00000338401.8
    Conserved Domains (1) summary
    cl17173
    Location:4106
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_001040162.3NP_001035252.1  methyltransferase-like 26 isoform d

    See identical proteins and their annotated locations for NP_001035252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) is shorter and has a distinct internal segment, compared to isoform a.
    Source sequence(s)
    BM827705, BU539308, DB499720
    Consensus CDS
    CCDS45367.1
    UniProtKB/Swiss-Prot
    Q96S19
    Related
    ENSP00000440475.2, ENST00000397664.8
    Conserved Domains (1) summary
    cl17173
    Location:4126
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. NM_001040165.3NP_001035255.1  methyltransferase-like 26 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two exons in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (g) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI146806, BU539308, DB499720
    Consensus CDS
    CCDS42090.1
    UniProtKB/Swiss-Prot
    Q96S19
    Related
    ENSP00000444460.2, ENST00000397665.6
    Conserved Domains (1) summary
    cl17173
    Location:4134
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. NM_001288710.2NP_001275639.1  methyltransferase-like 26 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (h) is shorter, compared to isoform 1.
    Source sequence(s)
    BP273946, BU539308, DB499720
    Consensus CDS
    CCDS73798.1
    UniProtKB/TrEMBL
    A0A087WYU2
    Related
    ENSP00000482089.1, ENST00000614890.4
    Conserved Domains (1) summary
    cl17173
    Location:4183
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. NM_032366.5NP_115742.3  methyltransferase-like 26 isoform a

    See identical proteins and their annotated locations for NP_115742.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK294482, DB499720
    Consensus CDS
    CCDS45368.1
    UniProtKB/Swiss-Prot
    Q96S19
    Related
    ENSP00000445926.2, ENST00000301686.13
    Conserved Domains (1) summary
    pfam06080
    Location:4203
    DUF938; Protein of unknown function (DUF938)

RNA

  1. NR_109976.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AW027232, BU539308, DB499720
  2. NR_109977.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294482, DB499720
    Related
    ENST00000568077.5
  3. NR_109978.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294482, BI762987, BU539308, DB499720
    Related
    ENST00000456420.6
  4. NR_109979.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BU539308, DB499720

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    634429..636364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522714.2XP_011521016.1  methyltransferase-like 26 isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:4120
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_011522713.2XP_011521015.1  methyltransferase-like 26 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:4270
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040163.1: Suppressed sequence

    Description
    NM_001040163.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001040164.1: Suppressed sequence

    Description
    NM_001040164.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_001040166.1: Suppressed sequence

    Description
    NM_001040166.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center