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ACBD6 acyl-CoA binding domain containing 6 [ Homo sapiens (human) ]

Gene ID: 84320, updated on 21-Mar-2023

Summary

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Official Symbol
ACBD6provided by HGNC
Official Full Name
acyl-CoA binding domain containing 6provided by HGNC
Primary source
HGNC:HGNC:23339
See related
Ensembl:ENSG00000230124 MIM:616352; AllianceGenome:HGNC:23339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable fatty-acyl-CoA binding activity and lipid binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.9), placenta (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ACBD6 in Genome Data Viewer
Location:
1q25.2-q25.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (180269653..180502577, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (179625056..179857576, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (180257365..180471712, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene quiescin sulfhydryl oxidase 1 Neighboring gene Sharpr-MPRA regulatory region 8966 Neighboring gene LIM homeobox 4 Neighboring gene LHX4 antisense RNA 1 Neighboring gene uncharacterized LOC124904702 Neighboring gene uncharacterized LOC105371637 Neighboring gene voltage dependent anion channel 1 pseudogene 4 Neighboring gene microRNA 3121 Neighboring gene uncharacterized LOC124904658 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10130 Neighboring gene ovarian adenocarcinoma amplified long non-coding RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins. Soupene E, et al. Biomolecules, 2022 Nov 22. PMID 36551154, Free PMC Article
  2. Requirement of the acyl-CoA carrier ACBD6 in myristoylation of proteins: Activation by ligand binding and protein interaction. Soupene E, et al. PLoS One, 2020. PMID 32108178, Free PMC Article
  3. ACBD6 protein controls acyl chain availability and specificity of the N-myristoylation modification of proteins. Soupene E, et al. J Lipid Res, 2019 Mar. PMID 30642881, Free PMC Article
  4. Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes. Soupene E, et al. J Lipid Res, 2015 Oct. PMID 26290611, Free PMC Article
  5. Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells. Soupene E, et al. J Lipid Res, 2008 May. PMID 18268358, Free PMC Article

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins.
    Title: Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins.
  2. ACBD6 proteins promote N-myristoylation in mammalian cells
    Title: ACBD6 protein controls acyl chain availability and specificity of the N-myristoylation modification of proteins.
  3. The acyl-CoA binding domain (ACB) and the ankyrin-repeat motifs (ANK) of ACBD6 can perform their functions independently. Interaction of ANK with NMT2 was necessary and sufficient to provide protection.
    Title: Requirement of the acyl-CoA carrier ACBD6 in myristoylation of proteins: Activation by ligand binding and protein interaction.
  4. ACBD6 gene, related to acyl-CoA binding, might play momentous roles in the initiation and development of consecutive Trauma-Induced Sepsis.
    Title: Identification of genes related to consecutive trauma-induced sepsis via gene expression profiling analysis.
  5. ligand binding properties of the NMT/ACBD6 complex can explain how the NMT reaction can proceed in the presence of the very abundant competitive substrate, C(16)-CoA.
    Title: Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.
  6. Findings provide evidence that the binding properties of ACBD6 are adapted to prevent its constant saturation by the very abundant C16:0-CoA and protect membrane systems.
    Title: Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  8. ACBD6 is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus.
    Title: Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2404

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
acyl-CoA-binding domain-containing protein 6
Names
acyl-Coenzyme A binding domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032360.4 → NP_115736.1  acyl-CoA-binding domain-containing protein 6

    See identical proteins and their annotated locations for NP_115736.1

    Status: VALIDATED

    Source sequence(s)
    AA085012, AK314112, BU170874
    Consensus CDS
    CCDS1339.1
    UniProtKB/Swiss-Prot
    Q9BR61
    UniProtKB/TrEMBL
    A0A024R915, A0A024R949, B2RAA8
    Related
    ENSP00000356567.3, ENST00000367595.4
    Conserved Domains (3) summary
    cd00204
    Location:165 → 261
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:191 → 222
    ANK; ANK repeat [structural motif]
    pfam00887
    Location:44 → 123
    ACBP; Acyl CoA binding protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    180269653..180502577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432083.1 → XP_047288039.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
    UniProtKB/TrEMBL
    A0A024R949

  2. XM_047432080.1 → XP_047288036.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
    UniProtKB/TrEMBL
    A0A024R949
    Related
    ENSP00000495710.1, ENST00000642319.1

  3. XM_047432082.1 → XP_047288038.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
    UniProtKB/TrEMBL
    A0A024R949

  4. XM_047432081.1 → XP_047288037.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
    UniProtKB/TrEMBL
    A0A024R949

  5. XM_047432085.1 → XP_047288041.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
    UniProtKB/TrEMBL
    A0A024R949

  6. XM_047432084.1 → XP_047288040.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
    UniProtKB/TrEMBL
    A0A024R949

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    179625056..179857576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339188.1 → XP_054195163.1  acyl-CoA-binding domain-containing protein 6 isoform X1

  2. XM_054339185.1 → XP_054195160.1  acyl-CoA-binding domain-containing protein 6 isoform X1

  3. XM_054339187.1 → XP_054195162.1  acyl-CoA-binding domain-containing protein 6 isoform X1

  4. XM_054339186.1 → XP_054195161.1  acyl-CoA-binding domain-containing protein 6 isoform X1

  5. XM_054339190.1 → XP_054195165.1  acyl-CoA-binding domain-containing protein 6 isoform X1

  6. XM_054339189.1 → XP_054195164.1  acyl-CoA-binding domain-containing protein 6 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BR61.1 GenPept UniProtKB/Swiss-Prot:Q9BR61

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