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ACBD6 acyl-CoA binding domain containing 6 [ Homo sapiens (human) ]

Gene ID: 84320, updated on 10-Apr-2024

Summary

Official Symbol
ACBD6provided by HGNC
Official Full Name
acyl-CoA binding domain containing 6provided by HGNC
Primary source
HGNC:HGNC:23339
See related
Ensembl:ENSG00000230124 MIM:616352; AllianceGenome:HGNC:23339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable fatty-acyl-CoA binding activity and lipid binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.9), placenta (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

See ACBD6 in Genome Data Viewer
Location:
1q25.2-q25.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (180269653..180502577, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (179625056..179857576, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (180257365..180471712, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2159 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180134845-180135502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180135503-180136160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180136161-180136816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180136817-180137474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180162034-180162705 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1382 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1383 Neighboring gene quiescin sulfhydryl oxidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1593 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180213501-180214248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180217481-180217981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180218267-180219247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180223097-180223616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180227074-180227843 Neighboring gene Sharpr-MPRA regulatory region 8966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180240649-180241576 Neighboring gene LIM homeobox 4 Neighboring gene MPRA-validated peak481 silencer Neighboring gene LHX4 antisense RNA 1 Neighboring gene MPRA-validated peak482 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:180295724-180296224 Neighboring gene MPRA-validated peak483 silencer Neighboring gene MPRA-validated peak484 silencer Neighboring gene uncharacterized LOC124904702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2162 Neighboring gene uncharacterized LOC105371637 Neighboring gene voltage dependent anion channel 1 pseudogene 4 Neighboring gene microRNA 3121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180470119-180470634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180470635-180471150 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:180471258-180471758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2164 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:180490465-180491664 Neighboring gene uncharacterized LOC124904658 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:180540570-180541769 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:180555052-180555235 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10130 Neighboring gene ovarian adenocarcinoma amplified long non-coding RNA Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:180601022-180601522 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:180601523-180602023 Neighboring gene MPRA-validated peak486 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:180679967-180680667 Neighboring gene xenotropic and polytropic retrovirus receptor 1 Neighboring gene uncharacterized LOC124904687

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC2404

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
acyl-CoA-binding domain-containing protein 6
Names
acyl-Coenzyme A binding domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032360.4NP_115736.1  acyl-CoA-binding domain-containing protein 6

    See identical proteins and their annotated locations for NP_115736.1

    Status: VALIDATED

    Source sequence(s)
    AA085012, AK314112, BU170874
    Consensus CDS
    CCDS1339.1
    UniProtKB/Swiss-Prot
    Q9BR61
    UniProtKB/TrEMBL
    B2RAA8
    Related
    ENSP00000356567.3, ENST00000367595.4
    Conserved Domains (3) summary
    cd00204
    Location:165261
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:191222
    ANK; ANK repeat [structural motif]
    pfam00887
    Location:44123
    ACBP; Acyl CoA binding protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    180269653..180502577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432083.1XP_047288039.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
  2. XM_047432080.1XP_047288036.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
    Related
    ENSP00000495710.1, ENST00000642319.1
  3. XM_047432082.1XP_047288038.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
  4. XM_047432081.1XP_047288037.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
  5. XM_047432085.1XP_047288041.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
  6. XM_047432084.1XP_047288040.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    179625056..179857576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339188.1XP_054195163.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
  2. XM_054339185.1XP_054195160.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
  3. XM_054339187.1XP_054195162.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
  4. XM_054339186.1XP_054195161.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
  5. XM_054339190.1XP_054195165.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61
  6. XM_054339189.1XP_054195164.1  acyl-CoA-binding domain-containing protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR61