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CCDC77 coiled-coil domain containing 77 [ Homo sapiens (human) ]

Gene ID: 84318, updated on 17-Jun-2019

Summary

Official Symbol
CCDC77provided by HGNC
Official Full Name
coiled-coil domain containing 77provided by HGNC
Primary source
HGNC:HGNC:28203
See related
Ensembl:ENSG00000120647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 7.0), lymph node (RPKM 3.3) and 24 other tissues See more
Orthologs

Genomic context

See CCDC77 in Genome Data Viewer
Location:
12p13.33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (389347..442642)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (498516..551811)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 13 Neighboring gene uncharacterized LOC102723544 Neighboring gene lysine demethylase 5A Neighboring gene Sharpr-MPRA regulatory region 4015 Neighboring gene uncharacterized LOC105369594 Neighboring gene Sharpr-MPRA regulatory region 4380 Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 3 Neighboring gene uncharacterized LOC105369595 Neighboring gene ninjurin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13183

Gene Ontology Provided by GOA

Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
coiled-coil domain-containing protein 77

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130146.2NP_001123618.1  coiled-coil domain-containing protein 77 isoform b

    See identical proteins and their annotated locations for NP_001123618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform.
    Source sequence(s)
    AC005844, BC006444, CX784327, DA711064
    Consensus CDS
    CCDS44781.1
    UniProtKB/Swiss-Prot
    Q9BR77
    Related
    ENSP00000412925.2, ENST00000412006.6
    Conserved Domains (1) summary
    TIGR02168
    Location:60295
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. NM_001130147.1NP_001123619.1  coiled-coil domain-containing protein 77 isoform b

    See identical proteins and their annotated locations for NP_001123619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform.
    Source sequence(s)
    AC005844, AK308216, BC006444, DC331633
    Consensus CDS
    CCDS44781.1
    UniProtKB/Swiss-Prot
    Q9BR77
    Related
    ENSP00000391870.1, ENST00000422000.5
    Conserved Domains (1) summary
    TIGR02168
    Location:60295
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  3. NM_001130148.2NP_001123620.1  coiled-coil domain-containing protein 77 isoform b

    See identical proteins and their annotated locations for NP_001123620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform.
    Source sequence(s)
    AC005844, BC006444, DC331633
    Consensus CDS
    CCDS44781.1
    UniProtKB/Swiss-Prot
    Q9BR77
    Related
    ENSP00000440554.1, ENST00000540180.5
    Conserved Domains (1) summary
    TIGR02168
    Location:60295
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  4. NM_032358.4NP_115734.1  coiled-coil domain-containing protein 77 isoform a

    See identical proteins and their annotated locations for NP_115734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC005844, BC006444, DA711064
    Consensus CDS
    CCDS8503.1
    UniProtKB/Swiss-Prot
    Q9BR77
    Related
    ENSP00000239830.4, ENST00000239830.9
    Conserved Domains (1) summary
    TIGR00618
    Location:57386
    sbcc; exonuclease SbcC

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    389347..442642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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