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VPS25 vacuolar protein sorting 25 homolog [ Homo sapiens (human) ]

Gene ID: 84313, updated on 7-Dec-2018

Summary

Official Symbol
VPS25provided by HGNC
Official Full Name
vacuolar protein sorting 25 homologprovided by HGNC
Primary source
HGNC:HGNC:28122
See related
Ensembl:ENSG00000131475 MIM:610907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DERP9; EAP20; FAP20
Summary
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in esophagus (RPKM 14.2), colon (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See VPS25 in Genome Data Viewer
Location:
17q21.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (42773436..42779600)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40925454..40931618)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 15 Neighboring gene RAMP2 antisense RNA 1 Neighboring gene receptor activity modifying protein 2 Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene cytochrome c oxidase assembly factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
shRNA knockdown of VPS25 (ESCRT-II component) impairs HIV-1 CA-p24 production when using wild type (HIV-1 LAI) and VSV-pseudotyped virus; HIV replication is enhanced by VPS25 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Knockdown of TSG101 impairs terminal cleavage of p24/p2 to p24 PubMed
gag SPRY2 associates with ESCR-II component EAP20 to promote HIV-1 Gag release PubMed
capsid gag HIV-1 release (as measured by CA-p24 levels) from cells involves VPS25 (EAP20) PubMed
gag Knockdown of TSG101 impairs terminal cleavage of p24/p2 to p24 PubMed
gag Knockdown of VPS25 (ESCRT-II component) decreases extracellular HIV-1 CA-p24 levels when using wild type (HIV-1 LAI) and VSV-pseudotyped virus PubMed
gag Knockdown of VPS25 (ESCRT-II component) impairs HIV-1 CA-p24 production when using wild type (HIV-1 LAI) and VSV-pseudotyped virus PubMed
p2 gag Knockdown of TSG101 impairs terminal cleavage of p24/p2 to p24 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • ESCRT-II complex, organism-specific biosystem (from KEGG)
    ESCRT-II complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
  • ESCRT-II complex, conserved biosystem (from KEGG)
    ESCRT-II complex, conserved biosystemStructural complex; Genetic information processing; Protein processing
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem (from REACTOME)
    Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystemMany plasma membrane proteins are in a constant flux throughout the internal trafficking pathways of the cell. Some receptors are continuously internalized into recycling endosomes and returned to th...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10540

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
ESCRT II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ESCRT II complex IDA
Inferred from Direct Assay
more info
PubMed 
ESCRT II complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vacuolar protein-sorting-associated protein 25
Names
ELL-associated protein of 20 kDa
ESCRT-II complex subunit VPS25
dermal papilla-derived protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032353.4NP_115729.1  vacuolar protein-sorting-associated protein 25

    See identical proteins and their annotated locations for NP_115729.1

    Status: REVIEWED

    Source sequence(s)
    BC006282
    Consensus CDS
    CCDS11438.1
    UniProtKB/Swiss-Prot
    Q9BRG1
    UniProtKB/TrEMBL
    A0A024R1X3
    Related
    ENSP00000253794.1, ENST00000253794.6
    Conserved Domains (1) summary
    pfam05871
    Location:10145
    ESCRT-II; ESCRT-II complex subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    42773436..42779600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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