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NUDT16L1 nudix hydrolase 16 like 1 [ Homo sapiens (human) ]

Gene ID: 84309, updated on 1-Aug-2020

Summary

Official Symbol
NUDT16L1provided by HGNC
Official Full Name
nudix hydrolase 16 like 1provided by HGNC
Primary source
HGNC:HGNC:28154
See related
Ensembl:ENSG00000168101 MIM:617338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDOS; TIRR
Expression
Ubiquitous expression in kidney (RPKM 5.2), prostate (RPKM 4.4) and 25 other tissues See more
Orthologs

Genomic context

See NUDT16L1 in Genome Data Viewer
Location:
16p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (4688930..4695859)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4743526..4745860)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mahogunin ring finger 1 Neighboring gene RNA, 7SL, cytoplasmic 850, pseudogene Neighboring gene microRNA 6769a Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 8628 Neighboring gene chromosome 16 open reading frame 71 Neighboring gene zinc finger protein 500

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11275

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
NOT m7G(5')pppN diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT m7G(5')pppN diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT m7G(5')pppN diphosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT nucleotide phosphatase activity, acting on free nucleotides IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT phosphodiesterase decapping endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
NOT mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
PubMed 
NOT snoRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tudor-interacting repair regulator protein
Names
NUDT16-like protein 1
nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1
protein syndesmos
syndesmos

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193452.1NP_001180381.1  tudor-interacting repair regulator protein isoform 2

    See identical proteins and their annotated locations for NP_001180381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC023830, BQ923183, BU739233, DA607298
    Consensus CDS
    CCDS59257.1
    UniProtKB/TrEMBL
    W4VSQ8
    Related
    ENSP00000468346.1, ENST00000586536.1
  2. NM_001370585.1NP_001357514.1  tudor-interacting repair regulator protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC023830
    Related
    ENSP00000464821.1, ENST00000590460.1
  3. NM_001370586.1NP_001357515.1  tudor-interacting repair regulator protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC023830
  4. NM_001370587.1NP_001357516.1  tudor-interacting repair regulator protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC023830
    Related
    ENSP00000466854.1, ENST00000586252.1
  5. NM_001370588.1NP_001357517.1  tudor-interacting repair regulator protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC023830
  6. NM_032349.3NP_115725.1  tudor-interacting repair regulator protein isoform 1

    See identical proteins and their annotated locations for NP_115725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK315456, BC006223, BU739233
    Consensus CDS
    CCDS10519.1
    UniProtKB/Swiss-Prot
    Q9BRJ7
    UniProtKB/TrEMBL
    B2RD96
    Related
    ENSP00000306670.5, ENST00000304301.10

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    4688930..4695859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255633.5XP_005255690.1  tudor-interacting repair regulator protein isoform X1

    Related
    ENSP00000458144.1, ENST00000405142.1
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