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PDCD2L programmed cell death 2 like [ Homo sapiens (human) ]

Gene ID: 84306, updated on 3-May-2020

Summary

Official Symbol
PDCD2Lprovided by HGNC
Official Full Name
programmed cell death 2 likeprovided by HGNC
Primary source
HGNC:HGNC:28194
See related
Ensembl:ENSG00000126249 MIM:615661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 7.2), fat (RPKM 2.8) and 25 other tissues See more
Orthologs

Genomic context

See PDCD2L in Genome Data Viewer
Location:
19q13.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (34404398..34426168)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (34895300..34917073)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene granule associated Rac and RHOG effector 1 Neighboring gene Sharpr-MPRA regulatory region 14193 Neighboring gene glucose-6-phosphate isomerase Neighboring gene RNA, 7SL, cytoplasmic 154, pseudogene Neighboring gene ubiquitin like modifier activating enzyme 2 Neighboring gene WT1 interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of programmed cell death 2-like (PDCD2L) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13096

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
programmed cell death protein 2-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353433.1NP_001340362.1  programmed cell death protein 2-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008747, AC092073
    Conserved Domains (1) summary
    pfam04194
    Location:234348
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain
  2. NM_032346.2NP_115722.1  programmed cell death protein 2-like isoform 1

    See identical proteins and their annotated locations for NP_115722.1

    Status: VALIDATED

    Source sequence(s)
    BC006146
    Consensus CDS
    CCDS12438.1
    UniProtKB/Swiss-Prot
    Q9BRP1
    Related
    ENSP00000246535.1, ENST00000246535.4
    Conserved Domains (1) summary
    pfam04194
    Location:236350
    PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    34404398..34426168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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