U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NUDT22 nudix hydrolase 22 [ Homo sapiens (human) ]

Gene ID: 84304, updated on 5-Jul-2025
Official Symbol
NUDT22provided by HGNC
Official Full Name
nudix hydrolase 22provided by HGNC
Primary source
HGNC:HGNC:28189
See related
Ensembl:ENSG00000149761 AllianceGenome:HGNC:28189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables UDP-sugar diphosphatase activity and metal ion binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in duodenum (RPKM 16.3), spleen (RPKM 14.4) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See NUDT22 in Genome Data Viewer
Location:
11q13.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64226258..64230269)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64216204..64220214)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63993746..63997488)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3462 Neighboring gene stress induced phosphoprotein 1 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:63972802-63973364 and GRCh37_chr11:63973365-63973927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4888 Neighboring gene FERM domain containing kindlin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63992564-63993286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63993887-63994406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63994407-63994924 Neighboring gene uncharacterized LOC124902687 Neighboring gene tRNA phosphotransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3467 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene vascular endothelial growth factor B

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. NUDT22 promotes cancer growth through pyrimidine salvage. Walter M, et al. Oncogene, 2023 Apr. PMID 36871087, Free PMC Article
  2. Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold. Carter M, et al. Structure, 2018 Feb 6. PMID 29413322
  3. Genome-wide association study of the child behavior checklist dysregulation profile. Mick E, et al. J Am Acad Child Adolesc Psychiatry, 2011 Aug. PMID 21784300, Free PMC Article
  4. New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496
  5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NUDT22 promotes cancer growth through pyrimidine salvage.
    Title: NUDT22 promotes cancer growth through pyrimidine salvage.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of the child behavior checklist dysregulation profile.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC13045

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP-mannose hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-sugar diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-sugar diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
Preferred Names
uridine diphosphate glucose pyrophosphatase NUDT22
Names
UDPG pyrophosphatase
UGPPase
nucleoside diphosphate-linked moiety X motif 22
nudix (nucleoside diphosphate linked moiety X)-type motif 22
nudix motif 22
NP_001122084.2
NP_001122085.2
NP_001258760.2
NP_115720.2
XP_047283655.1
XP_047283656.1
XP_047283657.1
XP_047283658.1
XP_047283659.1
XP_047283660.1
XP_047283661.1
XP_047283663.1
XP_054226150.1
XP_054226151.1
XP_054226152.1
XP_054226153.1
XP_054226154.1
XP_054226155.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128612.3 → NP_001122084.2  uridine diphosphate glucose pyrophosphatase NUDT22 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AP001453, AP006334
    Consensus CDS
    CCDS8061.1
    UniProtKB/Swiss-Prot
    C9JY06, Q71RD5, Q9BRQ3
    UniProtKB/TrEMBL
    J3KQJ3

  2. NM_001128613.3 → NP_001122085.2  uridine diphosphate glucose pyrophosphatase NUDT22 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode isoform b.
    Source sequence(s)
    AP001453, AP006334
    Consensus CDS
    CCDS44640.1
    Related
    ENSP00000407970.2, ENST00000441250.6

  3. NM_001271831.2 → NP_001258760.2  uridine diphosphate glucose pyrophosphatase NUDT22 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode isoform b.
    Source sequence(s)
    AP001453, AP006334
    Consensus CDS
    CCDS44640.1

  4. NM_032344.4 → NP_115720.2  uridine diphosphate glucose pyrophosphatase NUDT22 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AP001453, AP006334
    Consensus CDS
    CCDS8061.1
    UniProtKB/Swiss-Prot
    C9JY06, Q71RD5, Q9BRQ3
    UniProtKB/TrEMBL
    J3KQJ3
    Related
    ENSP00000279206.3, ENST00000279206.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64226258..64230269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427707.1 → XP_047283663.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X7

    UniProtKB/TrEMBL
    J3KQJ3

  2. XM_047427700.1 → XP_047283656.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X2

    UniProtKB/TrEMBL
    J3KQJ3
    Related
    ENSP00000401085.2, ENST00000428347.2

  3. XM_047427702.1 → XP_047283658.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X3

    UniProtKB/TrEMBL
    J3KQJ3

  4. XM_047427704.1 → XP_047283660.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X5

    UniProtKB/TrEMBL
    J3KQJ3

  5. XM_047427701.1 → XP_047283657.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X2

    UniProtKB/TrEMBL
    J3KQJ3

  6. XM_047427703.1 → XP_047283659.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X4

    UniProtKB/Swiss-Prot
    C9JY06, Q71RD5, Q9BRQ3
    UniProtKB/TrEMBL
    J3KQJ3

  7. XM_047427705.1 → XP_047283661.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X6

  8. XM_047427699.1 → XP_047283655.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X1

    UniProtKB/TrEMBL
    J3KQJ3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64216204..64220214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370180.1 → XP_054226155.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X7

    UniProtKB/TrEMBL
    J3KQJ3

  2. XM_054370176.1 → XP_054226151.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X2

    UniProtKB/TrEMBL
    J3KQJ3

  3. XM_054370178.1 → XP_054226153.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X3

    UniProtKB/TrEMBL
    J3KQJ3

  4. XM_054370179.1 → XP_054226154.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X5

    UniProtKB/TrEMBL
    J3KQJ3

  5. XM_054370175.1 → XP_054226150.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X1

    UniProtKB/TrEMBL
    J3KQJ3

  6. XM_054370177.1 → XP_054226152.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X2

    UniProtKB/TrEMBL
    J3KQJ3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BRQ3.3 GenPept UniProtKB/Swiss-Prot:Q9BRQ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools