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DDI2 DNA damage inducible 1 homolog 2 [ Homo sapiens (human) ]

Gene ID: 84301, updated on 8-Aug-2021

Summary

Official Symbol
DDI2provided by HGNC
Official Full Name
DNA damage inducible 1 homolog 2provided by HGNC
Primary source
HGNC:HGNC:24578
See related
Ensembl:ENSG00000197312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in esophagus (RPKM 7.7), kidney (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

See DDI2 in Genome Data Viewer
Location:
1p36.21
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (15617458..15669044)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15943953..15995539)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 179 pseudogene Neighboring gene CD24 molecule pseudogene 1 Neighboring gene regulator of solute carriers 1 Neighboring gene pleckstrin homology and RUN domain containing M2 Neighboring gene SLC25A34 and TMEM82 antisense RNA 1 Neighboring gene solute carrier family 25 member 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC14844

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to hydroxyurea IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein DDI1 homolog 2
Names
DDI1, DNA-damage inducible 1, homolog 2
DNA-damage inducible protein 2 (DDI2)
NP_115717.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032341.5NP_115717.3  protein DDI1 homolog 2

    See identical proteins and their annotated locations for NP_115717.3

    Status: VALIDATED

    Source sequence(s)
    AK057374, AK293006, AL121992, AL598343, BC006011
    Consensus CDS
    CCDS30607.1
    UniProtKB/Swiss-Prot
    Q5TDH0
    Related
    ENSP00000417748.1, ENST00000480945.6
    Conserved Domains (2) summary
    cd05479
    Location:221343
    RP_DDI; retropepsin-like domain of DNA damage inducible protein
    cd01796
    Location:176
    Ubl_Ddi1_like; ubiquitin-like (Ubl) domain found in the eukaryotic Ddi1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    15617458..15669044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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