U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 [ Homo sapiens (human) ]

Gene ID: 84300, updated on 25-Nov-2023

Summary

Official Symbol
UQCC2provided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase complex assembly factor 2provided by HGNC
Primary source
HGNC:HGNC:21237
See related
Ensembl:ENSG00000137288 MIM:614461; AllianceGenome:HGNC:21237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M19; Cbp6; MNF1; MC3DN7; C6orf125; C6orf126; bA6B20.2
Summary
This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in heart (RPKM 18.8), testis (RPKM 14.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See UQCC2 in Genome Data Viewer
Location:
6p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33696764..33711700, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33517949..33532883, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33664541..33679477, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:33557672-33558871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33559025-33559664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33560945-33561584 Neighboring gene long intergenic non-protein coding RNA 336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33566996-33567496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33567497-33567997 Neighboring gene gametogenetin binding protein 1 (pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33571503-33572004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33572005-33572504 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:33574668-33575174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33575775-33576317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33577246-33577832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33577833-33578418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17049 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33589316-33589501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33590023-33590572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33590573-33591121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33597027-33597903 Neighboring gene uncharacterized LOC124901305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33602349-33602895 Neighboring gene ITPR3 antisense RNA 1 Neighboring gene inositol 1,4,5-trisphosphate receptor type 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33618418-33618918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33618919-33619419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33624122-33624658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33625731-33626265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33626906-33627416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33636045-33636676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33636677-33637307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33641013-33641534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33658493-33659470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33659471-33660446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33660447-33661424 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:33662237-33663436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33665333-33666308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33672165-33672664 Neighboring gene uncharacterized LOC124901304 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33678073-33678970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24368 Neighboring gene microRNA 3934 Neighboring gene Sharpr-MPRA regulatory region 11056 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:33692274-33693024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33695430-33696209 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33696210-33696988 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33703405-33703659 Neighboring gene inositol hexakisphosphate kinase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33710674-33711363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33711622-33712515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33712516-33713408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33713409-33714302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33718585-33719144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33719703-33720261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33728947-33729550 Neighboring gene Sharpr-MPRA regulatory region 8162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33740622-33741320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33747376-33748316 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33748317-33749256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33750197-33751135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:33755871-33756420 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17057 Neighboring gene LEM domain nuclear envelope protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC14833

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ubiquinol-cytochrome c reductase complex assembly factor 2
Names
breast cancer-associated protein SGA-81M
cytochrome B protein synthesis 6 homolog
mitochondrial nucleoid factor 1
mitochondrial protein M19
NP_115716.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034147.1 RefSeqGene

    Range
    5052..19988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032340.4NP_115716.1  ubiquinol-cytochrome c reductase complex assembly factor 2

    See identical proteins and their annotated locations for NP_115716.1

    Status: REVIEWED

    Source sequence(s)
    AI688269, BC006007, BI604191, CN261727
    Consensus CDS
    CCDS4784.1
    UniProtKB/Swiss-Prot
    B2R4I0, Q9BRT2
    UniProtKB/TrEMBL
    V5IRT4
    Related
    ENSP00000476140.1, ENST00000607484.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    33696764..33711700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    33517949..33532883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)