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ING5 inhibitor of growth family member 5 [ Homo sapiens (human) ]

Gene ID: 84289, updated on 17-May-2020

Summary

Official Symbol
ING5provided by HGNC
Official Full Name
inhibitor of growth family member 5provided by HGNC
Primary source
HGNC:HGNC:19421
See related
Ensembl:ENSG00000168395 MIM:608525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p28ING5
Summary
This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in ovary (RPKM 3.6), skin (RPKM 3.2) and 25 other tissues See more
Orthologs

Genomic context

See ING5 in Genome Data Viewer
Location:
2q37.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (241687017..241729481)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242641456..242668896)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene autophagy related 4B cysteine peptidase Neighboring gene deoxythymidylate kinase Neighboring gene D-2-hydroxyglutarate dehydrogenase Neighboring gene uncharacterized LOC105373976

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23842, AC133528.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K14 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein acetylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inhibitor of growth protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330161.2NP_001317090.1  inhibitor of growth protein 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate promoter and differs in the 3' exon structure, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AC114730, AC133528
    Consensus CDS
    CCDS82585.1
    UniProtKB/TrEMBL
    A0A1B0GW41
    Related
    ENSP00000490767.1, ENST00000636051.1
  2. NM_001330162.2NP_001317091.1  inhibitor of growth protein 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' terminal exon compared to variant 1. The encoded isoform (3) has a shorter C-terminus than isoform 1.
    Source sequence(s)
    AC114730, AC133528, BC005370
    Consensus CDS
    CCDS82586.1
    UniProtKB/Swiss-Prot
    Q8WYH8
    Related
    ENSP00000385937.1, ENST00000406941.5
    Conserved Domains (2) summary
    cd15586
    Location:188226
    PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)
    pfam12998
    Location:6105
    ING; Inhibitor of growth proteins N-terminal histone-binding
  3. NM_032329.6NP_115705.2  inhibitor of growth protein 5 isoform 1

    See identical proteins and their annotated locations for NP_115705.2

    Status: REVIEWED

    Source sequence(s)
    AC133528, AF189286, AI701412, AK074422, AK128322, BC039028, BI962551, BQ187350
    Consensus CDS
    CCDS33425.1
    UniProtKB/Swiss-Prot
    Q8WYH8
    Related
    ENSP00000322142.6, ENST00000313552.10
    Conserved Domains (2) summary
    cd15685
    Location:187235
    PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)
    pfam12998
    Location:6105
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    241687017..241729481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005101.1XP_016860590.1  inhibitor of growth protein 5 isoform X4

  2. XM_017005102.2XP_016860591.1  inhibitor of growth protein 5 isoform X5

    Related
    ENST00000482774.5
    Conserved Domains (1) summary
    pfam12998
    Location:6105
    ING; Inhibitor of growth proteins N-terminal histone-binding
  3. XM_017005098.1XP_016860587.1  inhibitor of growth protein 5 isoform X2

  4. XM_017005097.1XP_016860586.1  inhibitor of growth protein 5 isoform X1

  5. XM_017005099.1XP_016860588.1  inhibitor of growth protein 5 isoform X3

RNA

  1. XR_001738993.2 RNA Sequence

  2. XR_427115.4 RNA Sequence

  3. XR_002959351.1 RNA Sequence

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