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NTPCR nucleoside-triphosphatase, cancer-related [ Homo sapiens (human) ]

Gene ID: 84284, updated on 7-Jun-2020

Summary

Official Symbol
NTPCRprovided by HGNC
Official Full Name
nucleoside-triphosphatase, cancer-relatedprovided by HGNC
Primary source
HGNC:HGNC:28204
See related
Ensembl:ENSG00000135778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THEP1; C1orf57; HCR-NTPase
Summary
The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in brain (RPKM 18.5), kidney (RPKM 18.3) and 25 other tissues See more
Orthologs

Genomic context

See NTPCR in Genome Data Viewer
Location:
1q42.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (232950611..232983882)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (233086277..233114548)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927711 Neighboring gene RNA, U1 small nuclear 74, pseudogene Neighboring gene uncharacterized LOC105373201 Neighboring gene uncharacterized LOC107985361 Neighboring gene pecanex 2 Neighboring gene ribosomal protein S7 pseudogene 3 Neighboring gene mitogen-activated protein kinase kinase kinase 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11383, MGC13186

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
nucleoside-triphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide phosphatase activity, acting on free nucleotides IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane HDA PubMed 

General protein information

Preferred Names
cancer-related nucleoside-triphosphatase
Names
human cancer-related NTPase
nucleoside triphosphate phosphohydrolase
nucleoside-triphosphatase C1orf57
NP_001316381.1
NP_001316382.1
NP_115700.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329452.2NP_001316381.1  cancer-related nucleoside-triphosphatase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL122003, BQ001389
  2. NM_001329453.2NP_001316382.1  cancer-related nucleoside-triphosphatase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA635564, AL122003, BC005102, BQ001389, HY133356
    UniProtKB/Swiss-Prot
    Q9BSD7
    Conserved Domains (1) summary
    cl21455
    Location:4102
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_032324.3NP_115700.1  cancer-related nucleoside-triphosphatase isoform 1

    See identical proteins and their annotated locations for NP_115700.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL122003, BC005102, BQ001389, HY133356
    Consensus CDS
    CCDS1597.1
    UniProtKB/Swiss-Prot
    Q9BSD7
    UniProtKB/TrEMBL
    Q5TDE9
    Related
    ENSP00000355587.4, ENST00000366628.10
    Conserved Domains (1) summary
    pfam03266
    Location:4182
    NTPase_1; NTPase

RNA

  1. NR_138024.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BG106026, BQ001389, HY133356
  2. NR_138025.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BF663221, BQ001389, HY133356
  3. NR_138026.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BQ001389, HY133356, W80669
  4. NR_138027.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BG473925, BQ001389
  5. NR_138028.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL122003, BC005102, BQ001389, DC332692, HY133356

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    232950611..232983882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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