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BTBD10 BTB domain containing 10 [ Homo sapiens (human) ]

Gene ID: 84280, updated on 9-Feb-2020

Summary

Official Symbol
BTBD10provided by HGNC
Official Full Name
BTB domain containing 10provided by HGNC
Primary source
HGNC:HGNC:21445
See related
Ensembl:ENSG00000148925 MIM:615933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GMRP1; GMRP-1
Expression
Ubiquitous expression in testis (RPKM 14.0), brain (RPKM 12.4) and 24 other tissues See more
Orthologs

Genomic context

See BTBD10 in Genome Data Viewer
Location:
11p15.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (13387996..13463297, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (13409555..13484838, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376558 Neighboring gene aryl hydrocarbon receptor nuclear translocator like Neighboring gene RN7SK pseudogene 151 Neighboring gene PTH promoter region Neighboring gene PTH negative calcium response element (nCARE) region Neighboring gene parathyroid hormone

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13007

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
BTB/POZ domain-containing protein 10
Names
BTB (POZ) domain containing 10
BTB (broad-complex tramtrack and bric-a-brac/pox virus and zinc finger) domain-containing protein 10
K+ channel tetramerization protein
epididymis secretory sperm binding protein
glucose metabolism-related protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297741.1NP_001284670.1  BTB/POZ domain-containing protein 10 isoform 3

    See identical proteins and their annotated locations for NP_001284670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate upstream exon in place of the first exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF329102, AI051522, AK298226
    Consensus CDS
    CCDS76388.1
    UniProtKB/TrEMBL
    B7Z503, D3DQW7
    Related
    ENSP00000435257.1, ENST00000528120.5
    Conserved Domains (1) summary
    pfam16017
    Location:120225
    BTB_3; BTB/POZ domain
  2. NM_001297742.1NP_001284671.1  BTB/POZ domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001284671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF329102, AI051522, AK316163
    Consensus CDS
    CCDS73261.1
    UniProtKB/Swiss-Prot
    Q9BSF8
    UniProtKB/TrEMBL
    D3DQW7
    Related
    ENSP00000431186.1, ENST00000530907.5
    Conserved Domains (1) summary
    pfam16017
    Location:176281
    BTB_3; BTB/POZ domain
  3. NM_032320.6NP_115696.2  BTB/POZ domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_115696.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has two alternate upstream exons in place of the first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF329102, AI051522
    Consensus CDS
    CCDS7811.1
    UniProtKB/Swiss-Prot
    Q9BSF8
    UniProtKB/TrEMBL
    D3DQW7
    Related
    ENSP00000278174.5, ENST00000278174.9
    Conserved Domains (1) summary
    pfam16017
    Location:168273
    BTB_3; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    13387996..13463297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018411.1XP_016873900.1  BTB/POZ domain-containing protein 10 isoform X5

    UniProtKB/TrEMBL
    B7Z503
    Conserved Domains (1) summary
    pfam16017
    Location:120225
    BTB_3; BTB/POZ domain
  2. XM_017018410.1XP_016873899.1  BTB/POZ domain-containing protein 10 isoform X4

  3. XM_017018409.1XP_016873898.1  BTB/POZ domain-containing protein 10 isoform X4

  4. XM_017018406.2XP_016873895.1  BTB/POZ domain-containing protein 10 isoform X2

    Conserved Domains (1) summary
    pfam16017
    Location:168273
    BTB_3; BTB/POZ domain
  5. XM_024448713.1XP_024304481.1  BTB/POZ domain-containing protein 10 isoform X3

    Conserved Domains (1) summary
    pfam16017
    Location:168273
    BTB_3; BTB/POZ domain
  6. XM_024448712.1XP_024304480.1  BTB/POZ domain-containing protein 10 isoform X2

    Conserved Domains (1) summary
    pfam16017
    Location:168273
    BTB_3; BTB/POZ domain
  7. XM_017018405.1XP_016873894.1  BTB/POZ domain-containing protein 10 isoform X1

RNA

  1. XR_001748002.2 RNA Sequence

  2. XR_001748001.2 RNA Sequence

    Related
    ENST00000527102.6
  3. XR_001748000.2 RNA Sequence

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