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PRADC1 protease associated domain containing 1 [ Homo sapiens (human) ]

Gene ID: 84279, updated on 13-Mar-2020

Summary

Official Symbol
PRADC1provided by HGNC
Official Full Name
protease associated domain containing 1provided by HGNC
Primary source
HGNC:HGNC:16047
See related
Ensembl:ENSG00000135617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP21; C2orf7
Expression
Ubiquitous expression in heart (RPKM 23.7), fat (RPKM 12.7) and 25 other tissues See more
Orthologs

Genomic context

See PRADC1 in Genome Data Viewer
Location:
2p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (73228006..73233284, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73455134..73460356, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene notochord homeobox Neighboring gene Sharpr-MPRA regulatory region 2018 Neighboring gene SMYD family member 5 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene F-box protein 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protease-associated domain-containing protein 1
Names
protease-associated domain-containing glycoprotein 21 kDa
protease-associated domain-containing protein of 21 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032319.3NP_115695.1  protease-associated domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_115695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding variant.
    Source sequence(s)
    BC005069, BM556790
    Consensus CDS
    CCDS1924.1
    UniProtKB/Swiss-Prot
    Q9BSG0
    Related
    ENSP00000258083.2, ENST00000258083.3
    Conserved Domains (1) summary
    cd02127
    Location:51168
    PA_hPAP21_like; PA_hPAP21_like: Protease-associated domain containing proteins like the human secreted glycoprotein hPAP21 (human protease-associated domain-containing protein, 21kDa). This group contains various PA domain-containing proteins similar to hPAP21. Complex ...

RNA

  1. NR_144358.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010913

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    73228006..73233284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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