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NOA1 nitric oxide associated 1 [ Homo sapiens (human) ]

Gene ID: 84273, updated on 17-Jun-2019

Summary

Official Symbol
NOA1provided by HGNC
Official Full Name
nitric oxide associated 1provided by HGNC
Primary source
HGNC:HGNC:28473
See related
Ensembl:ENSG00000084092 MIM:614919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTG3; hNOA1; C4orf14; hAtNOS1; mAtNOS1
Summary
The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in colon (RPKM 10.1), duodenum (RPKM 8.9) and 25 other tissues See more
Orthologs

Genomic context

See NOA1 in Genome Data Viewer
Location:
4q12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (56963350..56977606, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (57829516..57843826, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kazal type 2 Neighboring gene RE1 silencing transcription factor Neighboring gene RNA polymerase II subunit B Neighboring gene RNA, U6 small nuclear 998, pseudogene Neighboring gene insulin like growth factor binding protein 7 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3232

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with extrinsic component of mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nitric oxide-associated protein 1
Names
mitochondrial GTPase 3 homolog
nitric oxide synthase, mitochondrial (putative)
putative ortholog of Arabidopsis mitochondrial nitric oxide synthase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032313.4NP_115689.1  nitric oxide-associated protein 1

    See identical proteins and their annotated locations for NP_115689.1

    Status: REVIEWED

    Source sequence(s)
    AC069307, BC004894
    Consensus CDS
    CCDS3510.1
    UniProtKB/Swiss-Prot
    Q8NC60
    Related
    ENSP00000264230.4, ENST00000264230.5
    Conserved Domains (1) summary
    cl26335
    Location:139660
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    56963350..56977606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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