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POLDIP3 DNA polymerase delta interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 84271, updated on 9-Feb-2020

Summary

Official Symbol
POLDIP3provided by HGNC
Official Full Name
DNA polymerase delta interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:23782
See related
Ensembl:ENSG00000100227 MIM:611520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SKAR; PDIP3; PDIP46
Summary
This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in ovary (RPKM 49.2), bone marrow (RPKM 26.9) and 25 other tissues See more
Orthologs

Genomic context

See POLDIP3 in Genome Data Viewer
Location:
22q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (42583721..42614962, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (42979727..43010968, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene serine hydrolase like 2 Neighboring gene RNA, U6 small nuclear 513, pseudogene Neighboring gene ribosomal RNA processing 7 homolog B, pseudogene Neighboring gene RNA, U12 small nuclear Neighboring gene cytochrome b5 reductase 3 Neighboring gene ATP synthase membrane subunit g like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1649

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
poly(A)+ mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
polymerase delta-interacting protein 3
Names
46 kDa DNA polymerase delta interaction protein
RNA-binding protein P46
S6K1 Aly/REF-like target
polymerase (DNA) delta interacting protein 3
polymerase (DNA-directed), delta interacting protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278657.1NP_001265586.1  polymerase delta-interacting protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AK303419, AL137743, DC368557
    Consensus CDS
    CCDS74873.1
    UniProtKB/TrEMBL
    B4E0L0, F6VRR5, Q659C6
    Related
    ENSP00000397927.3, ENST00000451060.6
    Conserved Domains (2) summary
    COG0724
    Location:301424
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12681
    Location:297365
    RRM_SKAR; RNA recognition motif in S6K1 Aly/REF-like target (SKAR) and similar proteins
  2. NM_001363052.2NP_001349981.1  polymerase delta-interacting protein 3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL137743, Z93241
    Conserved Domains (1) summary
    cd12681
    Location:280341
    RRM_SKAR; RNA recognition motif in S6K1 Aly/REF-like target (SKAR) and similar proteins
  3. NM_032311.5NP_115687.2  polymerase delta-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_115687.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL160111, DC368557
    Consensus CDS
    CCDS14038.1
    UniProtKB/Swiss-Prot
    Q9BY77
    Related
    ENSP00000252115.5, ENST00000252115.10
    Conserved Domains (2) summary
    COG0724
    Location:284407
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12681
    Location:280348
    RRM_SKAR; RNA recognition motif in S6K1 Aly/REF-like target (SKAR) and similar proteins
  4. NM_178136.3NP_835237.1  polymerase delta-interacting protein 3 isoform 2

    See identical proteins and their annotated locations for NP_835237.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL160112, DC368557
    Consensus CDS
    CCDS14039.1
    UniProtKB/Swiss-Prot
    Q9BY77
    Related
    ENSP00000252116.5, ENST00000348657.6
    Conserved Domains (2) summary
    COG0724
    Location:255378
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12681
    Location:251319
    RRM_SKAR; RNA recognition motif in S6K1 Aly/REF-like target (SKAR) and similar proteins

RNA

  1. NR_103820.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL137743, DC368557
    Related
    ENST00000445215.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    42583721..42614962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029010.2XP_016884499.1  polymerase delta-interacting protein 3 isoform X2

  2. XM_017029011.2XP_016884500.1  polymerase delta-interacting protein 3 isoform X3

    Related
    ENSP00000408046.1, ENST00000454057.1
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