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POLR3GL RNA polymerase III subunit GL [ Homo sapiens (human) ]

Gene ID: 84265, updated on 6-Sep-2022

Summary

Official Symbol
POLR3GLprovided by HGNC
Official Full Name
RNA polymerase III subunit GLprovided by HGNC
Primary source
HGNC:HGNC:28466
See related
Ensembl:ENSG00000121851 MIM:617457; AllianceGenome:HGNC:28466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOFM; RPC32HOM; flj32422
Summary
Predicted to enable chromatin binding activity. Involved in transcription by RNA polymerase III. Located in nucleus. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 24.4), spleen (RPKM 14.6) and 25 other tissues See more
Orthologs
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Genomic context

See POLR3GL in Genome Data Viewer
Location:
1q21.1
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145927627..145978848)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (145081507..145095672)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145456236..145470400, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene gonadotropin releasing hormone receptor 2 (pseudogene) Neighboring gene RNA binding motif protein 8A Neighboring gene LIX1L antisense RNA 1 Neighboring gene limb and CNS expressed 1 like Neighboring gene conserved acetylation island sequence C12 enhancer Neighboring gene Sharpr-MPRA regulatory region 4010 Neighboring gene ankyrin repeat domain 34A Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:145455010-145456209 Neighboring gene thioredoxin interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3200, FLJ34890

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC7-like
Names
DNA-directed RNA polymerase III subunit G-like
RNA polymerase III 32 kDa beta subunit
RNA polymerase III subunit C7-like
RNA polymerase III subunit G like
RPC32-beta
RPC32-like protein
alternative RNA polymerase III subunit 32
polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like
polymerase (RNA) III subunit G like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330685.2NP_001317614.1  DNA-directed RNA polymerase III subunit RPC7-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC004355, BI914801, CN261802
    Consensus CDS
    CCDS81367.1
    UniProtKB/Swiss-Prot
    Q9BT43
    UniProtKB/TrEMBL
    A6NGX6
    Related
    ENSP00000358319.3, ENST00000369313.7
    Conserved Domains (1) summary
    pfam11705
    Location:16192
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
  2. NM_032305.3NP_115681.1  DNA-directed RNA polymerase III subunit RPC7-like isoform 1

    See identical proteins and their annotated locations for NP_115681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC004355, BI914801
    Consensus CDS
    CCDS72875.1
    UniProtKB/Swiss-Prot
    B1MVG5, Q9BT43
    Related
    ENSP00000358320.1, ENST00000369314.2
    Conserved Domains (1) summary
    pfam11705
    Location:16204
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    145927627..145978848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432062.1XP_047288018.1  DNA-directed RNA polymerase III subunit RPC7-like isoform X1

    UniProtKB/Swiss-Prot
    B1MVG5
  2. XM_047432063.1XP_047288019.1  DNA-directed RNA polymerase III subunit RPC7-like isoform X1

    UniProtKB/Swiss-Prot
    B1MVG5
  3. XM_005277431.5XP_005277488.1  DNA-directed RNA polymerase III subunit RPC7-like isoform X1

    See identical proteins and their annotated locations for XP_005277488.1

    UniProtKB/Swiss-Prot
    B1MVG5, Q9BT43
    Conserved Domains (1) summary
    pfam11705
    Location:16204
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    145081507..145095672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)