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HAGHL hydroxyacylglutathione hydrolase like [ Homo sapiens (human) ]

Gene ID: 84264, updated on 25-Nov-2021

Summary

Official Symbol
HAGHLprovided by HGNC
Official Full Name
hydroxyacylglutathione hydrolase likeprovided by HGNC
Primary source
HGNC:HGNC:14177
See related
Ensembl:ENSG00000103253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 1.8), spleen (RPKM 1.6) and 20 other tissues See more
Orthologs
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Genomic context

See HAGHL in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (726999..729715)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (777106..779715)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene coiled-coil domain containing 78 Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene Sharpr-MPRA regulatory region 977 Neighboring gene MSLN promoter region Neighboring gene mesothelin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2605

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydroxyacylglutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
hydroxyacylglutathione hydrolase-like protein
Names
GLO2-like/ RJD12
NP_001277066.1
NP_001277068.1
NP_001310564.1
NP_001310565.1
NP_001352211.1
NP_115680.1
XP_005255688.1
XP_005255689.1
XP_011521014.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290137.2NP_001277066.1  hydroxyacylglutathione hydrolase-like protein isoform 2

    See identical proteins and their annotated locations for NP_001277066.1

    Status: VALIDATED

    Source sequence(s)
    BC004353, BG821643, BX090134, Z98258
    Consensus CDS
    CCDS32354.1
    UniProtKB/Swiss-Prot
    Q6PII5
    Conserved Domains (3) summary
    PLN02469
    Location:1244
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:173251
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4172
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
  2. NM_001290139.2NP_001277068.1  hydroxyacylglutathione hydrolase-like protein isoform 2

    See identical proteins and their annotated locations for NP_001277068.1

    Status: VALIDATED

    Source sequence(s)
    BC004353, BX090134, CD050886, Z98258
    Consensus CDS
    CCDS32354.1
    UniProtKB/Swiss-Prot
    Q6PII5
    Related
    ENST00000389701.9
    Conserved Domains (3) summary
    PLN02469
    Location:1244
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:173251
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4172
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
  3. NM_001323635.2NP_001310564.1  hydroxyacylglutathione hydrolase-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    BI834617, BQ067068, DA056485, EL736395
    Consensus CDS
    CCDS32354.1
    UniProtKB/Swiss-Prot
    Q6PII5
    Conserved Domains (3) summary
    PLN02469
    Location:1244
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:173251
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4172
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
  4. NM_001323636.2NP_001310565.1  hydroxyacylglutathione hydrolase-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA489499, AW136334, DA056485, EL736395, Z98258
  5. NM_001365282.1NP_001352211.1  hydroxyacylglutathione hydrolase-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    Z98258
    Related
    ENSP00000456390.1, ENST00000561546.5
    Conserved Domains (1) summary
    PLN02469
    Location:1226
    PLN02469; hydroxyacylglutathione hydrolase
  6. NM_032304.4NP_115680.1  hydroxyacylglutathione hydrolase-like protein isoform 2

    See identical proteins and their annotated locations for NP_115680.1

    Status: VALIDATED

    Source sequence(s)
    AK293575, BC004353, BX090134, Z98258
    Consensus CDS
    CCDS32354.1
    UniProtKB/Swiss-Prot
    Q6PII5
    UniProtKB/TrEMBL
    B4DED4
    Related
    ENSP00000374353.3, ENST00000389703.8
    Conserved Domains (3) summary
    PLN02469
    Location:1244
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:173251
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4172
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    726999..729715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255631.4XP_005255688.1  hydroxyacylglutathione hydrolase-like protein isoform X1

    See identical proteins and their annotated locations for XP_005255688.1

    UniProtKB/Swiss-Prot
    Q6PII5
    Related
    ENSP00000341952.4, ENST00000341413.8
    Conserved Domains (2) summary
    cd07723
    Location:4172
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
    cl25711
    Location:173202
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
  2. XM_005255632.1XP_005255689.1  hydroxyacylglutathione hydrolase-like protein isoform X3

    See identical proteins and their annotated locations for XP_005255689.1

    Conserved Domains (3) summary
    TIGR03413
    Location:6245
    GSH_gloB; hydroxyacylglutathione hydrolase
    pfam16123
    Location:173242
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4172
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
  3. XM_011522712.1XP_011521014.1  hydroxyacylglutathione hydrolase-like protein isoform X2

    Conserved Domains (3) summary
    PLN02469
    Location:1243
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:172250
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:4171
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207112.1: Suppressed sequence

    Description
    NM_207112.1: This RefSeq was permanently suppressed because there is insufficient support for the transcript and the protein.
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