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HSDL2 hydroxysteroid dehydrogenase like 2 [ Homo sapiens (human) ]

Gene ID: 84263, updated on 4-May-2020

Summary

Official Symbol
HSDL2provided by HGNC
Official Full Name
hydroxysteroid dehydrogenase like 2provided by HGNC
Primary source
HGNC:HGNC:18572
See related
Ensembl:ENSG00000119471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf99; SDR13C1
Expression
Ubiquitous expression in fat (RPKM 44.0), liver (RPKM 33.8) and 24 other tissues See more
Orthologs

Genomic context

See HSDL2 in Genome Data Viewer
Location:
9q32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (112379909..112472410)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115142189..115234685)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene HNF4 motif-containing MPRA enhancer 25 Neighboring gene ribosomal protein L32 pseudogene 22 Neighboring gene chromosome 9 open reading frame 147 Neighboring gene KIAA1958 Neighboring gene INTS3 and NABP interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of hydroxysteroid dehydrogenase like 2 (HSDL2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25855, MGC10940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hydroxysteroid dehydrogenase-like protein 2
Names
short chain dehydrogenase/reductase family 13C member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195822.1NP_001182751.1  hydroxysteroid dehydrogenase-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001182751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AK098721, AL162732, BC004331, DB052480
    Consensus CDS
    CCDS56582.1
    UniProtKB/Swiss-Prot
    Q6YN16
    UniProtKB/TrEMBL
    A0A024R159
    Related
    ENSP00000381783.1, ENST00000398803.1
    Conserved Domains (2) summary
    pfam02036
    Location:246339
    SCP2; SCP-2 sterol transfer family
    cl25409
    Location:8175
    SDR; Short-chain dehydrogenases/reductases (SDR)
  2. NM_032303.5NP_115679.2  hydroxysteroid dehydrogenase-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_115679.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK098721, AY093428, BC004331, BC095451
    Consensus CDS
    CCDS43864.1
    UniProtKB/Swiss-Prot
    Q6YN16
    Related
    ENSP00000381785.3, ENST00000398805.8
    Conserved Domains (2) summary
    cd09762
    Location:8248
    HSDL2_SDR_c; human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs
    pfam02036
    Location:319412
    SCP2; SCP-2 sterol transfer family

RNA

  1. NR_036651.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK098721, AK303645, AL162732, BC004331, DB052480

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    112379909..112472410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519091.3XP_011517393.1  hydroxysteroid dehydrogenase-like protein 2 isoform X1

    Conserved Domains (2) summary
    cd09762
    Location:8248
    HSDL2_SDR_c; human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs
    pfam00106
    Location:12197
    adh_short; short chain dehydrogenase
  2. XM_017015204.2XP_016870693.1  hydroxysteroid dehydrogenase-like protein 2 isoform X2

    Conserved Domains (2) summary
    pfam02036
    Location:144238
    SCP2; SCP-2 sterol transfer family
    cl21454
    Location:1100
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_017015205.2XP_016870694.1  hydroxysteroid dehydrogenase-like protein 2 isoform X2

    Conserved Domains (2) summary
    pfam02036
    Location:144238
    SCP2; SCP-2 sterol transfer family
    cl21454
    Location:1100
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_017015203.2XP_016870692.1  hydroxysteroid dehydrogenase-like protein 2 isoform X2

    Conserved Domains (2) summary
    pfam02036
    Location:144238
    SCP2; SCP-2 sterol transfer family
    cl21454
    Location:1100
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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