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FBXW9 F-box and WD repeat domain containing 9 [ Homo sapiens (human) ]

Gene ID: 84261, updated on 23-Nov-2021

Summary

Official Symbol
FBXW9provided by HGNC
Official Full Name
F-box and WD repeat domain containing 9provided by HGNC
Primary source
HGNC:HGNC:28136
See related
Ensembl:ENSG00000132004 MIM:609074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbw9; MEC-15
Summary
Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 5.8), kidney (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

See FBXW9 in Genome Data Viewer
Location:
19p13.13
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12688916..12696900, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12799730..12807445, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene deoxyhypusine synthase Neighboring gene Sharpr-MPRA regulatory region 9902 Neighboring gene G protein subunit gamma 14 Neighboring gene transportin 2 Neighboring gene small nucleolar RNA, C/D box 135 Neighboring gene small nucleolar RNA, C/D box 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10870

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
F-box/WD repeat-containing protein 9
Names
F-box and WD-40 domain protein 9
F-box and WD-40 domain-containing protein 9
F-box and WD-40 repeat containing protein 9
specificity factor for SCF ubiquitin ligase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032301.3NP_115677.2  F-box/WD repeat-containing protein 9

    See identical proteins and their annotated locations for NP_115677.2

    Status: VALIDATED

    Source sequence(s)
    AK123037, AW083348, DA079240
    Consensus CDS
    CCDS12278.2
    UniProtKB/Swiss-Prot
    Q5XUX1
    Related
    ENSP00000376945.3, ENST00000393261.8
    Conserved Domains (2) summary
    sd00039
    Location:177222
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:170413
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    12688916..12696900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260096.4XP_005260153.1  F-box/WD repeat-containing protein 9 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:20294
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:6499
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:17250
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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